The Expression Of ENO1 And M2-PK In Human Gastric Carcinomas And Its Clinical Significance

Objective To investigate the comparison of enolase-a(ENO1) and tumor M2 pyruvate kinase(M2-PK) expression in gastric cancer and benign gastric tissue, to study the association and clinicopathological significance of ENO1 and M2-PK expression in gastric cancer.Methods The expression of ENO1 and M2-PK in 55 paraffin-embedded specimens of gastric cancer and 23 paraffin-embedded specimens of benign gastric tissue was detected by SP immunohistochemistry.Specimens of gastric cancer were divided into groups based on parameters such as age,gender,differentiation grade,depth of invasion,lymph node metastasis,TNM staging and so on. The correlation of ENO1 expression to M2-PK expression, and their correlations to the clinicophathologic features of gastric cancer were analyzed.Results1. The positive rate of ENO1 was significantly higher in gastric cancer than in benign gastric tissue (67.3% vs.30.4%, P<0.01), and closely related to differentiation grade (P<0.01), depth of invasion (P<0.01), lymph node metastasis (P<0.05) and TNM staging(P<0.05).2. The positive rate of M2-PK was significantly higher in gastric cancer than in benign gastric tissue (78.2% vs.39.1%, P<0.01), and closely related to differentiation grade (P<0.05), depth of invasion (P<0.05).3. The expression of ENO1 was positively correlated to that of M2-PK (r=0.5729, P<0.05).Conclusion The up-regulation of ENO1 and M2-PK expression may play important roles in the oncogenesis and progression of gastric cancer. The ENO1 and M2-PK may take a synergistic effect in the infiltration and the metastasis of the tumor, which should be new targets of molecular targeted therapy.