Effect Of Diabetes On The Expression Of BMP-2 During The Bone Healing Of Alveolar Defect In Rats

Objective: To investigate the effect of diabetes on the expression of bone morphogenetic protein - 2 (BMP-2) during the various bone healing period of alveolar defect.Methods: 48 male SD rats were randomly divided into diabetes group(n=24) and control group(n=24), Diabetic ratswere induced by intraperitoneal injection of streptozotocin (STZ),alveolar defect were created by the diabetic duration time,6 rats for each group were scarified respectively at 1th,2th,4th,8th then the alveolar bone were processed for histological examination ,the expression of BMP-2 in different periods(1,2,4,8 weeks)of alveolar defect healing of rat was investigated by immunohistochemistry method, The optical density (OD) of BMP-2 was analysed and compared between groups.Results: Osteopenia in diabetes group ware observed.The OD of BMP - 2 in the control group was statistically greater than that in the test group 1 and 2 weeks after alveolar defect . At 4 and 8 weeks,the expression of BMP-2 in the control group were decreased,no statistical difference was found in BMP -2 expression between these two groups.Conclusion:Diabetes may affect the formation of BMP-2,while lead to a reduction in bone healing. Diabetes is able to affect the differentiation of mesenchymal stem cells,while lead to less osseointegration. Therefore,primary stability were decreased .