Relationship Between Angiotensin ⅡType 1 Receptor/Autoantibodies In Plasma And Blood Pressure

Background: Angiotensin II type 1 receptor is closely related to hypertension, and new evidence has suggested that the autoantibodies to AT₁R are present in hypertensive people.Objective: To investigate the relationship of angio- tensin II type 1 receptor (AT₁R), antibodies against angiotensin II Type 1 receptor (AT₁R-AA) and blood pressure.Methods: One hundred and thirty-eight subjects were enrolled and separated into three groups according to the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7): normotensive (≤120/80 mm Hg, n=31), pre- hypertensive (120—139/80—89 mm Hg, n=39) and hypertensive (≥140/90 mm Hg, n=68) groups. Plasma AT₁R and AT₁R-AA were detected by Enzyme-linked immunosorbent assay (ELISA), tumor necrosis factor-α(TNF-α), endothelin-1 (ET-1) and angiotensin II (Ang II) by radioimmunity. Results: 1) Plasma levels of AT₁R/ AT1- AA, TNF-α, ET-1 and Ang II are increased with blood pressure levels. 2) Plasma AT₁R/AT₁R-AA are positively correlated with systolic blood pressure,diastolic blood pressure, mean arterial pressure, TNF-α, ET-1 and Ang II, Ang II are also positively correlated with systolic blood pressure,diastolic blood pressure, mean arterial pressure and ET-1. 3) Multipule linear regression analysis showed that AT₁R, AT₁R-AA and Ang II are independent predictors for systolic blood pressure, mean arterial pressure, AT₁R, AT₁R-AA are independent predictors for diastolic blood pressure.Conclusion: The expression levels of plasma AT₁R/AT₁R-AA may reflect the levels of blood pressure. And AT₁R-AA is closely related with inflammatory factors, which may also play an important role in the progress of hypertension.