Evaluation Of Plasma LOX-1 And Adiponectin Level In Coronary Artery Disease Patients Accompanied With Metabolic Syndrome

ObjectiveTo evaluate the plasma lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and adiponectin level in coronary artery disease (CAD) patients accompanied with metabolic syndrome.MethodsThis study was carried out at the Department of Cardiology in the Xiangya Hospital of Central South University, China, from August 2009 to June 2010,30 Coronary artery disease (CAD) patients with mean age of 66 years (23 males and 7 females),30 CAD plus MS patients with mean age of 61 years (13 males and 17 females),30 MS patients with mean age of 53 years (23 males,7 females). As a control 30 healthy subjects with mean age of 51 years (22 males,8 females) were enrolled from Xiang ya medical center. For all the study subjects, preformed questionnaire were used to collect data and also collected the peripheral blood sample aseptically from the anticubital vein for the measurement of LOX-1 and adiponectin by ELISA technique.ResultsSystolic and Diastolic blood pressure in CAD+MS (142±9mmHg/82±7 mmHg) group, MS (136±6 mmHg/74±7mmHg) group and CAD (129±10mmHg/77±7mmHg) group were higher than control (124±8 mmHg/72±5mmHg) group respectively, the differences were statistically significant (P<0.05).BMI in CAD+MS (27.2±1 Kg/m2) group, MS (25.6±1 Kg/m2) group and CAD (23.7±1.3 Kg/m2) group were higher than control (21.1±1.5 Kg/m2) group, were significantly different (P<0.05).Plasma TG (2.1±1.4mmol/L), FBS (6.2±0. mmol/L), AST (23.5±4.8 U/L), ALT (21.2±4 U/L), Cr (89.3±16 mg/L), UA (314.7±55.1 mmol/L) and hs-CRP (12.0±8.5 mg/L) levels were higher in CAD+MS group as compared with control group TG (0.84±0.3mmol/L), FBS (4.5±0.3 mmol/L), AST (11.2±3.6U/L), ALT (14.5±4.5U/L), Cr (71.0±9.8 mg/L), UA (251.9±42 mmol/L) and hs-CRP (0.7±0.8mg/L), were significantly different (P><0.05).The CAD group shows higher BUN (5.5±0.9 mmol/L) level than the CAD+MS (5.3±1 mmol/L) group, MS (4.8±1.4 mmol/L) group and the control (3.9±0.6 mmol/L) group, were significantly different (P<0.05).The highest plasma LOX-1 level was found in CAD+MS (435.9±105.9 pg/ml) group, which was followed by CAD (196.2±40.4 pg/ml) group and MS (140.9±15 pg/ml) group. In control group it was (87.1±8.5 pg/ml).The result shows that the difference between control and diseased groups were statistically significant (P<0.001). On the contrary, the lowest adiponectin level was found in CAD+MS (263.6±26.6μg/L) group, which was followed by CAD (369.9±20.7μg/L) group and MS (450.8±25μg/L) group. In control group it was (510.9±29.3μg/L). The result shows that the difference between control and diseased groups were statistically significant (P<0.05, P<0.001). There were no significant differences in plasma LOX-1 and adiponectin level in patients with different ages and gender. Plasma LOX-1 level was changed negatively and linearly (R2=0.721) correlated with adiponectin level in different groups.ConclusionPlasma levels of LOX-1 are increased in CAD but this increased is more obvious in patients accompanied with MS. Plasma levels of ADP are decreased in CAD and the decrease is more remarkable in patients accompanied with MS.