Pre-emptive Analgesia Effect And Safety Of Parecoxib Sodium In Patients Undergoing Maxillofacial Postoperative Analgesia

Objective:Patient who undergoing maxillofacial operation aiways have different degree of pain and anxiety levels because of surgery trauma and special anatomical position. These factors serious influence the rest and healing of patients. Opiates is a traditional drugs in postoperative analgesia, but their adverse effects such as nausea, vomiting, respiratory depression and the operation near air way are deeply limited the use of postoperative analgesia in Maxillofacial surgery. parecoxib sodium, the injectable cyclooxygenase-2 selective inhibitor, has been proved not only to have efficacy in the treatment of pain and inflammation, but also to have a gastrointestinal safety profile and little effect on platelet aggregation and kidney function. In this article, we are going to study the pre-emptive analgesia effect and safety of parecoxib sodium in patients undergoing Maxillofacial postoperative analgesia.Methods:Sixty ASAⅠ～Ⅱpatients aged 18-65 yr undergoing Maxillofacial surgery. were randomly divided into three groups:Group A(n=20), Group B (n=20) and Group C(n=20).30 minutes before anesthesia- induced and the end of operation, Group A Received intravenous 2ml normal saline and morphine 4mg (4ml), Group B received intravenous 4ml normal saline and parecoxib 40mg(4ml), Group C Received intravenous parecoxib 20mg(4ml) and parecoxib 40mg (4ml). The extubation time, waking time, recover time of orientation, sleep time, postoperative agitation, fever or not were observered and recorded.The intensity of pain was measured by using a visual analogue scale(VAS,0-10,0=no pain,10=worst pain) and recorded at 1,3,6,10, 18,24 hour after operation. sedation score were evaluated at 15min 30min 45min after extubation The adverse effects such as dizziness, urinary retention, nausea,vomiting, respiratory depression were observered for 24h after operation.Resuits:No significant difference were found in the age, body weight, height, sex, anethesia time and types of operation performed among the three groups. Group A in waking time, extubation time, reorientation time were significantly longer than that of Group B and Group C. Sedation score at 15min 30min after extubation in Group B and Group C were significantly lower than that of Group A. The agritation was remarkably suppressed in Group A and Group C than that of Group B. There was no significantly difference in VAS at 1,3,6h after operation among the three groups, but in VAS at 1Oh after operation, Group B and Group C were significantly lower than that of Group A. Group C in VAS scale at 18,24h after operation.were lower than that of Group A and Group B. Group B and Group C caused fewer side-effect and fever than that of Group A. Patients in Group C had a better sleep time than that of Group A and Group C.Conclusion:When used in patient pre-emptive analgesia in maxillofacial surgery, Paracoxib soduim may provide a safe and efficient condition...