Effect Of Parecoxib Sodium For Preemptive Analgesia On Analgesic Effect In Patients After Abdominal Surgery

Objective: To observe the effect of parecoxib sodium on preventive analgesia for open cholecystectomy in patients with the effect opostoperative analgesic.Method: Selected patients undergoing elective cholecystectomy were 60 cases,were randomly divided into two groups: control group(group C)and parecoxib sodium group(P group),30 cases in each group.Each group of patients did not use preoperative medication.After admission,routine monitoring of electrocardiogram(ECG),blood pressure(NIBP)and pulse oxygen saturation(SpO2)were performed.General anesthesia after induction,endotracheal intubation under photopic visual laryngoscope.Intraoperative anesthesia was maintained by total intravenous anesthesia with continuous intravenous infusion of propofol and remifentanil to maintain intraoperative blood pressure fluctuations not exceeding 20% of basal values.During the operation,all the fluids were heated by liquid.The proportion of 2:1 to the ratio of crystal to glue was entered,and the speed of transfusion was adjusted according to the amount of bleeding during operation.The operation began at20 min:C before skin incision group intravenous injection of 0.9% sodium chloride physiological 2 ml,group P intravenous injection of parecoxib 40 mg.The abdomen was closed before surgery two groups of patients were given dezocine 0.08 mg/kg intravenously,surgical skin closure,stop infusion of propofol and Reventa Ni,the three connecting intravenous postoperative analgesia pump and open.After operation,the patient was provided with an endotracheal tube,a simple respiratory sac,and assisted respiration into the recovery room.Two groups were recorded the recovery time,extubation time,consciousness recovery time,extubation Riker score(SAS),the incidence of agitation and shivering;record after 2 h,4 h,8 h,12 h,24 h pain score(VASscore),postoperative analgesia and postoperative compressions after the dizziness,nausea and vomiting,the incidence of respiratory depression.The agitation score was Riker sedation and agitation scale(SAS),and the pain score was scored by the pain visual analogue scale(VAS).Results: There was no significant difference in recovery time,extubation time and recovery time between the two groups.Compared with C group,the SAS score was significantly lower in group P(P<0.05).Compared with group C,group P extubation SAS score was significantly lower than that in group C(P<0.05)and the incidence of agitation after extubation in group P was significantly lower than that of group C(P<0.05);group P at each time point after operation VAS scores were lower than those of group C,and the postoperative analgesia pressing times was less than group C,the difference was statistically significant(P<0.05).Compared with group C,the incidence of postoperative nausea and vomiting in group P was significantly lower than that in group C,the results were statistically significant(P <0.05).Conclusion: The application of parecoxib sodium preemptive analgesia can reduce the incidence of emergence agitation;and can reduce the dosage of analgesics after surgery,it is worthy of clinical application.