The Primary Study Of Coagulopathy In Lung Cancer Patients

Background and objective:Lung cancer was a serious disease which did harm to the life and health of human. Patients with malignant tumor had procoagulative phenotype owing to higher values of fibrinogen and coagulation indexes. VTE(Venous thromboembolism) was one of the important complications of cancer patients,who with VTE always had a poor prognosis. We would assay a part of coagulate plasma markers(eg. thrombin-antithrombin complex,TAT and Thrombomodulin,TM) of lung cancer patients in this study. The objective was to explore whether TAT and TM could be as the high-risk plasma markers leading to increased incidence of VTE of lung caner patients,and if high plasma levels of TAT and TM implied poor prognosis of lung caner patients.Materials and methods:Fifty-seven patients with lung cancer(6 patients with VTE on the occasion) were evaluated. Twenty-five normal subjects served as controls. All patients and controls underwent an assessment of coagulation and fibrinolysis indexes before treatment. Blood samples were collected for plasma. We assayed the plasma levels of TAT and TM using method of ELISA. Data were expressed as mean±S.D. for quantitative variables. The comparison between patients and controls for quantitative variables was performed by the One-Way ANOVA test. The statistical significance was determined using the exact P value. P<0.05 was considered as significant.Results:Lung cancer patients at baseline had a hypercoagulative phenotype when compared with normal subjects. The plasma levels of TAT and TM of lung cancer patients ware higher than normal subjects. The plasma levels of TAT and TM of VTE in lung cancer patients compared with lung cancer patients was no significant difference.The plasma levels of TAT of lung cancer patients inⅢB-Ⅳstage was higher than in I-IIIA stage.Conclusion:The plasma levels of TAT and TM could not be as the high-risk plasma markers leading to increased incidence of VTE of lung caner patients. The high plasma levels of TAT implied poor prognosis of lung caner patients.