The Association Between Physical Activities And Benign Prostatic Hyperplasia

ObjectiveTo investigate the severity of lower urinary tract symptoms (LUTS) of study population, and to explore the association of physical activity, such as recreational and occupational physical activity with the risk of BPH.MethodsA hospital based case control study was conducted between July 2009 and December 2010, including 180 male aged 55~90 years'residents who had been surgically treated on account of BPH which was histopathologically confirmed a final diagnosis in Jinzhou as case group. A total of 180 patients who had been admitted to the same hospitals for many different diseases not related with prostatic conditions were used as controls. Cases and controls were taken for 1:1 pair-matching. All subjects were interviewed during their hospital stay, using a standardized structured questionnaire that included information on socio-demographic characteristics, life habits, physical activity (recreational and occupational physical activity), Data on physical activity were obtained via an International Physical Activity Questionnaires (IPAQ). LUTS data were collected from subjects using the International Prostate Symptom Score (IPSS). The Quality of Life (QOL) was also used to evaluate the effect of urinary symptoms on participants'qualities of life. SPSS 13.0 statistical analysis software was used to analyze the correlation of dietary factors and development of BPH. Odds ratios (OR) and corresponding 95% confidence intervals (95% CI) were estimated using multivariable conditional logistic regression models to assess the association between physical activity and BPH. Results1. Total physical activity (OR =0.442, P =0.001), moderate physical activity (OR =0.654, P =0.015) and heavy manual labor (OR =0.506, P =0.001) were associated with an increased risk of BPH after multivariable conditional logistic regression analysis was conducted.2. There was no significant difference among men with occupational physical activity <2h/w(P =0.784), however, those with physical activity 2~4h/w (OR =0.468, P =0.011), 5~7h/w (OR =0.485, P =0.015) and >7h/w (OR =0.404, P =0.013) had a decreased risk of BPH compared with those no physical activity. the odds ratio of BPH decreased significantly with enhancement of physical activity, and dose-response relationship between physical activity and BPH was apparent.3. The proportion of men reported having obstructive LUTS was higher than those with irritative symptoms. The occurrence rate of clinical LUTS and the numbers of men with moderate to severe LUTS were progressing with aging.4. In IPSS, nocturia score was the highest, followed by pollakisurie score.Conclusions1. Total physical activity, moderate physical activity and heavy manual labor may decrease the risk of BPH, and the odds ratio of BPH decreased significantly with enhancement of physical activity.2. Subjects with heavy/strenuous physical activity had a decreased risk of BPH compared with those with sitting physical activity, however, there was no significant difference among men with standing and average separately physical activity.3. In IPSS, nocturia score was the highest, and the irritative symptoms are more severe than obstructive symptoms.BPH and LUTS are inevitable outcomes with aging, but physical activity is the protective factor of BPH. Thus, the occurrence of BPH can be prevented and delayed by avoiding the life style of sitting for long and keeping exercising actively.