Correlation Between Metabolic Syndrome And Lower Urinary Tract Symptoms In Patients With Benign Prostatic Hyperplasia

Objective: Investigate the association between metabolic syndrome(MetS)and lower urinary tract symptoms(LUTS)in patients with benign prostatic hyperplasia(BPH).Methods: 908 patients with benign prostatic hyperplasia who were hospitalized in the Affiliated Hospital of Qingdao University from October 2015 to December 2018 due to lower urinary tract symptoms were selected.The patients were divided into two groups according to whether they had metabolic syndrome or not,MetS group: BPH combined with MS,132 cases in total,non-Met S group: single BPH,776 cases in total.General patient data,physical examination data,laboratory examination data,prostate ultrasound examination results,and BPH related indicators were collected retrospectively;the international prostate symptom score(IPSS),the storage stage score,and the urination period score were calculated according to the "Guidelines for the Diagnosis and Treatment of Urological Diseases in China"(2014 edition).Data analysis was performed using SPSS 22.0 software.Results:(1)There was no significant difference in the average age,smoking and drinking ratio between the MetS group and the non-MetS group(P>0.05).The prevalence of abdominal obesity,hypertension,diabetes and coronary heart disease in the MetS group were 84.8%,29.5%,46.2% and 23.5%,respectively,which were significantly higher than that in the non-MetS group(P<0.05).(2)The FPG,TG,LDL-C,TC,SUA and creatinine in the Met S group were significantly higher than those in the non-MS group.The LDL-C and glomerular filtration rate were significantly lower than those in the non-MetS group(P<0.05).(3)There was no significant difference in the mean PSA,PV,and residual urine volume between the MetS group and the non-Met S group(P>0.05),but Qmax of the MetS group were significantly lower than those of the non-Met S group.(4)IPSS,storage period score and urinary period scores of MetS group were 26.7 ±6.3,12.2 ± 2.7 and 14.5 ± 4.7,respectively.The differences of IPSS and storage stage scores between the MetS group and the non-MetS group were statistically significant(P<0.05),but there was no significant difference in urination period scores between different group(P>0.05).(5)The scores of IPSS and storage stage scores were increased with the number of MetS component(P<0.05),but the urination period scores showed no regular changes(P>0.05).The scores of IPSS and storage period were positively correlated,and the correlation coefficient was statistically significant(P<0.05).IPSS was positively correlated with the urinary period score,with no statistical significance(P>0.05).(6)The IPSS scores of abdominal obesity and hypertension were significantly increased(P<0.05),but high TG,low HDL-C and hyperglycemia had no significant effect on IPSS(P>0.05).Conclusion: Metabolic syndrome can aggravate the symptoms of lower urinary tract in patients with benign prostatic hyperplasia.Prevention and treatment of metabolic syndrome may play a role in improving the symptoms of lower urinary tract in patients with benign prostatic hyperplasia.