The Value Of Quantitative Analysis Of ^99mTcO₄^- Thyroid Imaging In The Differentiated Diagnosis Of Thyroid Nodule

ObjectiveTo investigate the value of quantitative analysis of thyroid imaging in the differential diagnosis of thyroid nodule and to provide the basis for further treatment of patients.MethodsThyroid imaging had been finished for 165 patients with thyroid nodules. According to the pathologic results, thyroid nodules were divided into 131 cases of benign nodules and 34 cases of malignant nodules. Groups of benign nodules were divided into different groups according to different pathological types respectively. The results were analyzed by quantitatively. Then we can obtain cervical arterial-thyroid transit time(CTTT); blood ratio of thyroid nodule and thyroid(TNB/TB); blood ratio of thyroid nodule and carotid artery(TNB/CAB); the ratio of thyroid nodule and salivary gland(TN/SG); the ratio of thyroid nodule and thyroid(TN/T). The difference of quantitative parameter between benign and malignant nodules were compared. The difference of quantitative parameter within the groups of benign nodules were compared.Results1,Comparing each parameter of thyroid imaging between the malignant and benign nodules(1)The CTTT of malignant nodules was lower than that of benign nodules,there was significant difference(P<0.01). The TNB/TB and the TNB/CAB of malignant nodules were higher than that of benign nodules, there were significant differences(P<0.01). The TN/T of malignant nodules was lower than that of benign nodules,there was significant difference(P<0.01).(2)The TN/SG of malignant nodules was lower than that of benign nodules, there was no significant difference(P>0.05).2. Comparing each parameter of thyroid imaging within the groups of benign nodulesThe CTTT, TNB/TB, TNB/CAB, TN /SG and TN/T were compared within the groups of benign nodules,there were no significant differences(P>0. 0 5).3. ROC curve analysis showed that: The sensitivity and specificity of CTTT, TNB/TB, TNB/CAB and TN/T for diagnosis of thyroid nodule were 82.4%, 73.1%; 85.4%, 85.3%; 80%, 61.8%; 85.3%, 66.2% respectively. Combined quantitative parameter of CTTT, TNB/TB, TNB/CAB in thyroid dynamic imaging respectively with TN/T in thyroid static imaging, then the sensitivity, specificity and accuracy for diagnosis of benign and malignant nodules were 67.65%, 90.00%, 85.36%;70.59%, 93.08%, 88.41%;50.00%, 88.45%, 80.49% respectively.Conclusions1. Quantitative analysis of thyroid imaging has an important value for differential diagnosis thyroid nodule between benign and malignant.2. It has a certain degree sensitivity, specificity and accuracy for differential diagnosis thyroid nodule if quantitative parameter in thyroid dynamic imaging combine with that in static imaging.