The Experimental Study Of Xiao Shuan Yin's Decoction On Hemorheology From The Rabbit's Model About Deep Vein Thrombosis

Objective:This study was designed to bolt through the observation by Xiao Shuan yin fed the rabbit model of lower extremity DVT to change the body's blood rheology, Study the affect made by Xiao Shuan yin on lower extremity DVT animal hemorheology, make clearly that Xiao Shuan yin have ability to control hemorheology, at the base on the use of Xiao Shuan yin prevention, and observe the effects of key indicators of the impact of observed, Drink for the prevention of lower extremity DVT Xiao Shuan yin to provide laboratory evidence. At the same time compared with the saline group on the camera, Xiao Shuan yin confirmed lower limb DVT preventive effect, make Xiao Shuan yin further comparison with the low molecular weight heparin effect drink, And its evaluation of safety and practicality, to further explore the treatment of DVT drink consumption bolt mechanism for laying the foundation hemorheology.Methods:The 40 rabbits were randomly divided into four groups:A group (control group), B group (model group), C group (Xiao Shuan yin group), D group (low molecular weight heparin group) 10. With 3% sodium pentobarbital anesthesia (1 ml/Kg), The B, C, D groups of intimal damage to the femoral vein caused by venous occlusion. Intravenous ultrasound test showed that successful model, The rabbits were fed with drugs before and after modeling, check before modeling, and modeling the first 2 days after the success of the first 9 days,20 days, changes of hemorheology, including viscosity and low shear whole blood protein, high whole blood viscosity Cut protein, prothrombin time, fibrinogen, etc.Result:The experiment shows:â‘ Xiao Shuan yin consumption after modeling can significantly improve clinical signs in rabbits;â‘¡Xiao Shuan yin consumption after modeling can significantly improve the hemorheology in rabbits index was weaker than low molecular weight heparin and blank control group, were better than the control group (P<0.05).â‘¢Xiao Shuan yin can be significantly improved after modeling the four indicators of blood coagulation in rabbits, the role of low molecular weight heparin with the same, were better than the control group (P<0.05),â‘£Color Doppler:The results showed that drinking and low molecular weight heparin elimination bolt can significantly reduce the incidence of DVT, were better than the control group(P<0.05). Conclusion:Destruction of vascular endothelial method can create animal model of deep vein thrombosis; Chinese medicine Xiao Shuan yin can be significantly improved bolt rheology and decreased blood viscosity, And the intrinsic coagulation pathway by inhibiting the extrinsic coagulation pathway and Inhibit the formation of thromboplastin, to the role of antithrombotic therapy.