Observation Of HbAlc Cut-points Corresponding To Patients With Different Glucose Intolerances In Kunming Area

Objective To observe HbAlc cut-points corresponding to patients with different glucose intolerances in Kunming area. Methods (1) A total of 472 subjects (217 male and 255 female) were included in kunming area. All subjects underwent a 82.5g oral glucose (contains a molecular of H2O) tolerance test(OGTT) and HbAlc measurement.(2)Based on 1999 WHO criteria, the study subjects were divided into three groups:normal glucose tolerance (NGT), impaired fasting glucose (IFG) and (or) impaired glucose tolerance (IGT) and diabetes (DM) group. Based on receiver operating characteristic curves, optimum sensitivity and specificity were derived for defining HbA1c cut- points for IFG, IGT, DM.Results Mean±SD values of HbAlc among subjects with NGT, IFG and (or) IGT, DM were (6.06±0.11)%,(6.63±0.11)%,(8.70±2.08)%. For IFG, the optimal cut -point of HBA1C was 6.7%; for IGT, the optimal cut -point of HbA1c was 6.6%. When diabetes was defined on FPG, the optimal cut -point of HbA1c was 7.1%; when diabetes was defined on 2hPG, the optimal cut -point of HbAlc was 7.1%; when diabetes was defined on FPG and (or) 2hPG, the optimal cut -point of HbA1c was 7.0%.conclusions HbAlc for diagnosis of cut-point level is related to methodology,geographical,ethnic differences etc.