Sanqi Oral Solution On The Impact Of Platelet Activity In Diabetic Kidney Disease

ObjectivesTo objective of platelet activation markers P-selectin and the relevance of each factor in Diabetic kidney disease. And to P selectin was observed index, to observe the efficacy of Sanqi oral solution.MethodsSelecting case of 70 patients met the inclusion criteria from the Department of Endocrinology and the Nephrology of the Guangdong Provincial Hospital from December 2009 to December 2010. Development of inclusion and exclusion criteria. General information collected in all patients, testing the blood routine, coagulation, liver and kidney function, blood glucose, blood lipids, P selectin (Ps), urinary albumin excretion rate. Observation the correlation between of P selectin and biochemical. General information under both the biochemical indicators will be included patients were divided into treatment group and control group. control group given only glucose and blood pressure lowering based treatment. Treatment group on the basis of the treatment taking additional Sanqi oral solution, a stilbene, tid. After 8 weeks, Observing the changes in the level of P selectin.ResultBetween the treatment and control groups in age, gender, disease duration, body mass index, platelet count, blood lipids and renal function and glycosylated hemoglobin was no significant difference, (P>0.005), omparable.Plasma P selectin levels and course of diabetic nephropathy, blood lipids, urinary albumin was positively correlated, r were 0.545,0.649,0.514,0.518, but not with platelet counts of no significant correlation (r=0.288).After Sanqi oral solution treatment, plasma P selectin levels significantly decreased compared with before treatment, (P=0.049). ConclusionPlasma P selectin levels and course of diabetic nephropathy, blood lipids, urinary albumin was positively correlated, this suggests that P selectin in the development of diabetic nephropathy.There patients with diabetic nephropathy in vivo platelet activation, and with the progress of the disease, more serious degree of platelet activation.After Sanqi oral liquid treatment, plasma P selectin levels significantly decreased compared with before treatment, this suggests that sanqi oral inhibit platelet activation.