Traditional Chinese Medicine Enema Treatments AECOPD Phlegm And Blood Obstructing Lung Of P38MAPK Influence Of Signaling Pathways

Background:Chronic obstructive pulmonary disease (COPD) with worldwide has high morbidity and mortality. At present, widely considered COPD and pulmonary ascular lung parenchyma characterized by chronic inflammation of airway inflammation, and the original basis aggravating is acute exacerbations of AECOPD. But COPD repeated acute exacerbation will accelerate its worse lung function, the direct impact on the disease mortality and prognosis. Recent studies find, mitogen activated protein kinase (MAPK) is signaling pathways in inflammatory reaction disease occurrence and development in a control function. p38MAPK signaling pathways in the airway inflammatory reaction of disease and play an important role in the inflammation, given the close relationship between p38 pathways inhibitors reduce application specific cytokines, promote inflammation factors such as mediators of generation, this is treatment period of acute exacerbation of COPD new mentality.Objective:This topic is in Chinese medicine theory, combined with the tutor WuWeiSheng under the guidance of the clinical experience, western medicine therapy with conventional clyster of AECOPD period phlegm and blood stasis before and after the treatment of patients with lung resistance p38MAPK and related indexes variation, hoping to find in AECOPD of traditional Chinese medicine with p38MAPK clyster period of signaling pathways relationship.Method:60 Cases of patient were randomly divide into two groups. Both groups were treated by routine medicine and the treatment groups were treated by enema of taohechengqitang 20min with a course of 6days. To observed the changes of the major clinical symptom, Treatment end that compared with two groups of clinical symptoms and two groups p38MAPK phosphorylation level, routine blood, TNF-α, IL-8, blood gas analysis and pulmonary function, electrolyte, liver and kidney function of each index changes.Result:Two groups of gender, age, factors and duration of the length of the constituent, ratios of differences (P>0.05) was statistically significant, indicating that the treatment group and control group in patients with gender, age, and the length of the composition of basic equilibrium; Two groups of total significant efficiency significant difference (P<0.05); the total effective rate no obvious difference (P> 0.05). Two groups in p38MAPK phosphorylation level express, the WBC, NEU, EOSand TNF-αand IL-8 significant difference (P<0.05), the TCM enema therapy suppresses p38MAPK signaling pathways leading to the activation expression part; In electrolyte, liver and kidney function of each index no difference obvious (P>0.05); Effect of the treatment group than in control group. Two groups of clinical symptom scores before and after treatment, blood gas analysis and lung function of each index by statistics test changes existing statistically significant (P<0.05), the TCM enema therapy for AECOPD exacerbation phlegm and blood resistance lung type patients achieved good curative effect.Conclusion:The traditional enema combined with western medicine conventional treatments for AECOPD phlegm and blood stasis resistance lung type can inhibit the part p38MAPK signaling pathways, and can shorten the activation of the clinical symptoms alleviate pulmonary infection control time and shortening the time and improve the blood oxygen partial pressure and improve patients'lung function and no electrolytes disturbance and liver and kidney function damage, the clinical curative effect is better than pure western conventional treatment, is a more effective clinical treatment.