Application Of Arteriovenous Transit Time In The Study Of Transplanted Kidney Perfusion Imaging

Objective: To investigate the appropriate dose of SonoVue for arteriovenous transit time imaging in transplanted kidney, to reasearch the critical value of arteriovenous transit time in transplanted kidney with function stable phase, and it's application in the differential diagnosis of acute rejection(AR) and chronic allograft nephropathy(CAN).Methods: (1) 15 transplanted kidney patients with renal function stable phase were injected with SonoVue of 1.2 ml, 1.4 ml, 1.6 ml respectively; coded pulse inversion imaging(CPI ), time-intensity curve(TIC ), quality of fit (QOF), arrival time (AT), rise time (RT), mean transit time (mTT), time to peak (TTP), artery transit time (RATT) and vein transit time (RVTT) were conducted through Logiq9 ultrasonic diagnosis apparatus and sonoliver analysis software. Then the arteriovenous transit time (RAVTT) and appropriate dose of SonoVue were calculated out. (2) coded pulse inversion imaging(CPI), time-intensity curve(TIC) and curvilinear parameter conducted with 1.4 ml SonoVue were analyzed through TIC method in 30 transplanted kidney patients with renal function stable phase. (3) CPI images, TIC curve and curvilinear parameter were analyzed in 17 acute rejection(AR) cases, 17 chronic allograft nephropathy(CAN) cases, and 30 transplanted kidney patients with renal function stable phase. To research the application of arteriovenous transit time in differential diagnosis of acute rejection(AR) and chronic allograft nephropathy(CAN).Results: (1) There is statistical significe between imaging quality, QOF with 1.2 ml SonoVue group and 1.4 ml group, 1.6 ml group (P < 0.05) . No statistical significe was observed between RATT,RVTT,RAVTT with 1.2 ml group and 1.6 ml group (P >0.05). There is also no statistical significe between 1.4 ml group and 1.6 ml group (p > 0.05).(2) In 30 transplanted kidney patients with renal function stable phase, the mean artery transit time and vein transit time was 9.44±2.32 seconds and 11.27±2.25 seconds respectively, mean arteriovenous transit time was 2.07±0.45 seconds. (3)The mean artery transit time and vein transit time was 10.22±2.36 seconds and 12.65±2.29seconds respectively, and mean arteriovenous transit time was2.54±0.71 seconds in 17 AR cases. (4) The mean artery transit time and vein transit time was 10.72±1.52 seconds and 13.98±1.50 seconds respectively, and mean arteriovenous transit time was 3.26±0.91 seconds in 17 CAN cases.Conclusions: (1) The appropriate dose of SonoVue was 1.4 ml for contrast-enhanced ultrasound conducted in transplanted kidney with function stable phase. (2) Arteriovenous transit time may become a new useful indicator to evaluate the function of transplanted kidney and differentiated diagnosis of acute rejection(AR) and chronic allograft nephropathy(CAN). in transplanted kidney.