Diagnosis Of Chronic Rejection Of Allogenic Transplanted Kidneys By Ultrasonic Contrast

ObjectiveTo examine chronic rejection (CR) features of transplanted kidneys under ultrasonic contrast and find valuable parameters for CR diagnosis by analyzing time intensity curve (TIC).Methods46patients who took kidney transplantation more than3months before were selected and divided into no-rejection and CR according to a plasma creatinine standard of110μmol/L(males) and90μmol/L(females). The patients with a higher creatinine were pathologically proved to have CR. LOGIQ E9from GE Company was taken and Sonovue contrast was administered intravenously with a dose of0.12mg/kg to examine kidney perfusion. Interested parts of ultrasonic performance in the two groups were selected to draft TIC and the following parameters were analyzed: cortex peak strength (Al), cortex peak time(Ttop1), medulla peak time (Ttop2), difference between Ttopl and Ttop2(△TtoP), cortex area under TIC (Areal), medulla area under TIC (Area2) and difference between Areal and Area2(△Area).ResultsCR transplanted kidneys had a lower filling strength and slower filling speed than others. Except in Area2(P=0.678), significant differences were found in the other parameters between the two groups(P<0.05), especially in Al,△TtoP, Areal and△Area(P<0.01). ConclusionsUltrasonic contrast on CR transplanted kidneys have characteristic features. Parameters Al,△TtoP, Areal and△Area are valuable for CR diagnosis.