Study On Quality Evaluation Of The Effective Components In Safflower-semen Persicae And Their Preparations

Safflor yellow was the main effective components of safflower, semen persicae oil was the main effective components of semen persicae. Their pharmacology was clear. It prepares safflower- semen persicae soft capsule, in the form of compatibility with effective constituents, then research the quality evaluation method of the material and finished product, in this issue.Through the research of extraction and purification of safflor yellow, a new process was established. The content of residues is in compliance with applicable regulations. It can prepare high-purity safflor yellow in the new process, it contains 99% of the total safflor yellow,20% of hydroxy safflor yellow about.52.17% of total safflor yellow or 94.10% of hydroxy safflor yellow can be reserved. To analysis the sold safflor yellow with color value, It concludes that the color value is main about of the content of the total safflor yellow. The content of main composition in the homemade safflower yellow is more than the sold safflor yellow.The main composition of safflor yellow was complicated, using biological titer measurement can be evaluated more comprehensively, such as the measurement of total reducing force.Excepting oleic acid,linoleic acid, n-hexadecanoic acid, semen persicae oil contains benzaldehyde, squalene, tocopherol, beta sitosterol, and fucosterol.After the analysis and comparison of the fat-soluble composition in different varieties of semen persicae.And these components have important pharmacological effects. Different varieties of semen persicae existed obvious species differences by similarity and cluster analysis. It is feasible to extract massively semen persicae oil by heat squeezing, and the rate of 50%. The method, HPLC simultaneously determination the content f beta sitosterol and squalene in the semen persicae medicinal or the fat-soluble composition of semen persicae, was established, and the relevant quality standards was established too. On the dried basis, the content of semen persicae oil in semen persicae, should not be less than 37%; the content of beta sitosterol in semen persicae, should not be less than 0.07%, the content of squalene in semen persicae, should not be less than 0.01%; the content of beta sitosterol in semen persicae oil, should not be less than 0.16%; the content of squalene in semen persicae oil, should not be less than 0.02%. The light semen persicae is rich in resources, the main components were studied firstly, that provided theoretical basis in application.Based on the above of experiment results and the compatibility research of safflower- semen persicae, in the form of compatibility with effective constituents, in the compatibility of safflor yellow and semen persicae oil, prepared safflower- semen persicae soft capsule, then researched the quality evaluation method and established the relevant quality standards. For Chinese medicine objectification, modernization and internationalization laid a foundation.