| Objective: Arteriosclerotic obliterans, (ASO) is a systemic disease of atherosclerosis important part, and its display arterial intimal thickening, the secondary thrombus and calcification occluded artery may lead to stenosis as a result of unreasonable and even a group of chronic ischemic disease . The disease on the age of 50 is common in middle-aged men, of which the distal abdominal aorta and iliac - femoral - popliteal artery and others, most likely involved in the arteries, while the latter can involve the popliteal artery distal arterial. ASO can be distributed into a multi-level and multi-segment. With the problem of changing of China's aging and diet, the incidence rate will continue to increase. With further research on the ASO , we found that Chinese traditional medicine has a certain advantages and good prospects. The topics to Chinese dialectical theory of governance as a theoretical basis, prescription benefit qi Astragalus reuse, with the power of its blood circulation of qi, to play its anti-atherogenic, protecting blood vessels. Chuanxiong the blood circulation of qi, dispelling wind pain. Salvia stasis, Zheng Jia Xiaozheng casual, warm pain network. Fang Chuanxiong take Salvia combined to achieve stasis, temperature and pain of the power network. Use the system to relieve Hanning aconite yang. Gui warm through the blood circulation, and cold-pass network, with the system of monkshood ease Hanning signs. Health Hawthorn focus on the power of qi stasis. Dragon of a through the meridians, promoting blood circulation of power. Cyathula function expelling wind and dampness, pass through the blood circulation, and longer than stasis, as quoted in the blood down.Leeches are with antithrombotic and anticoagulant effect. Shan Jia blood circulation longer than the gun, with longer clotting time and reduce blood clotting. Curcuma, Tri for the commonly used drugs on compatibility, there are Poxue the power of qi. Shi Sanwei drugs are to warm the meridians, promoting blood circulation as a theoretical basis. It is based on observation of the peripheral blood of CD62p, CD63 expression level and arteriosclerosis obliterans of the relationship between blood stasis. It contrast with Xuefuzhuyu oral application to explore the effectiveness of the treatment side.Method:1 Direct immunofluorescence of flow cytometry detected 80 cases of lower extremity arterial occlusive disease patients and control group in peripheral blood of CD62p, CD63 expression levels.2 80 patients with arteriosclerosis obliterans patients (this study, the patients were from Hebei Province Chinese Medicine Hospital of Hebei Medical University Hospital of the surgery) were randomly divided into two groups, the treatment group was given Wen jing tong luo fang (the main party is : Astragalus mongholious 60g, Salvia miltiorrhiza 30g, monkshood 20g, Allolobophora caliginosa trapezoides 15g, Szechwan Lovage Rhizome 30g, Hawthorn Fruit 10g, cyathulae,radix 15g, Cassia Twig 15g, Common Burreed Tuber 15g, Zedoray Rhizome 15g, leech 9g, Stir-baked Squama Manitis 9g, Prepared Liauorice Root 6g) 50 cases. Control group is 30 cases which was treated with Xuefuzhuyu.3 Visibility dicision3.1 According to the Ministry of Health in 1997 by enacting the "Chinese drug therapy (thromboangiitis obliterans) guidelines for clinical research", we follow the patients with lower limb skin temperature, color, pain, dorsal artery fluctuations, intermittent claudication, etc. to develop Grading.3.2 To determine its visibility efficacy index calculation, efficacy = (1 - total score after treatment/ pretreatment score)×100%3.3 Total visibility evaluation standard. According to The association of Integrative Medicine - the efficacy of the Commission of peripheral vascular disease standards ,we use the method of nimodipine. Then the evaluation criteria are divided into: invalid, valid, effective, basic recovery . 4 The effiction of dicision4.1 measured indicators:4.1.1 blood-fat levels: high density lipoprotein (HDL), low density lipoprotein (LDL), total cholesterol (TC), triglyceride (TG)4.1.2 hemorheology: sedimentation equation K value, high shear whole blood viscosity, erythrocyte aggregation index, low shear whole blood viscosity, erythrocyte rigidity index, in peripheral blood plasma viscosity.4.1.3 CD62p, CD63 expression levels.4.2 security indicators:4.2.1 Physical Examination4.2.2 Physical Examination of blood, urine, stool occult blood occult blood will increase.4.2.3 liver function and renal function.4.3 Observation point: we will measure security indicators and measured indicators before and after the test.visual indicators is tested before and after the treatment, and on the 10th,20th,30th ,there will be other measure, but only before and after treatment were comparedResults:1 ASO patients is much more significantly than Control group on CD62p, CD63. So the two groups are significantly different (P <0.05)2 There is no significant difference between Wen Luo Qu Ban Tong Mai Fang and Xuefuzhuyu in gender and age. (P> 0.05).3 There is a similar treatment between Wen Luo Qu Ban Tong Mai Fang and Xuefuzhuyu. The two groups in HDL, LDL, TC, TG are no significant statistical difference (P> 0.05).4 Wen Luo Qu Ban Tong Mai Fang has a increased in hemorheology between the two groups , such as the high shear whole blood viscosity and fibrinogen .There is a significant difference between the two groups (P <0.05)5 Wen Luo Qu Ban Tong Mai Fang is much more significantly than Xuefuzhuyu on CD62p, CD63. The two groups are significantly different (P <0.05) Conclusion:1 We find that ASO patients is much more significantly than Control group on CD62p, CD63.2 There is a big help to improve symptoms , such as the pain of numb , pulselessness , pallor , paresthesia and others.3 It is show that it can change hemorheological indices , and cut lower blood cholesterol, triglyceride and low density lipoprotein cholesterol, increase high-density lipoprotein concentration.4 According to the indices of CD62p, CD63 , we find that Wen Luo Qu Ban Tong Mai Fang can change the indices of CD62p, CD63 of ASO5 It shows that the effect of medicion explore hypocoagulable states, regulation of vascular endothelial function, suppression and elimination of blood clots, to improve blood circulation . |
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