208 Cases Of Inflammatory Bowel Disease Clinical And Pathological Retrospective Analysis

Background and Objective:Inflammatory bowel disease includes ulcerative colitis and Crohn's disease, which common to Europe and the United States as the representative of the western countries, its etiology and pathogenesis remains unclear. In recent years, the incidence increased gradually in China, has become a focus of clinical research. Investigate the incidence of inflammatory bowel disease of ulcerative colitis was 11.6/10 million, Crohn's disease was 1.4/10 million, the environment, genetic, and other pathogen and immune imbalance caused by interaction of multiple factors. Inflammatory bowel disease has become more complicated by reports of increased colon cancer, inflammatory bowel cancer Asia-Pacific region lack the large-scale survey reported that the current colitis mucosal atypical hyperplasia of more concern. By analyzing the correlation between course of inflammatory bowel disease and microscopic lesions type and the detection rate of atypical hyperplasia, to explore how the malignant inflammatory bowel disease for early detection and early treatment.Methods:Select January 2006 to December 2009 Sir Run Run Shaw Affiliated Hospital of Zhejiang University,208 patients with inflammatory bowel disease clinical data of patients, including 111 patients with ulcerative colitis, and 97 patients with Crohn's disease. Recorded age of onset, duration, gender, diseased region, endoscopic and pathological features. The course of disease, diseased region, the different characteristics of endoscopic lesions and detection of atypical hyperplasia were analyzed.Results:111 cases of UC patients, male 58, female 53 cases, male to female ratio of 1.1:1; CD patients with 97 cases,62 males and 35 female, male to female ratio of 1.8:1. UC main clinical manifestations of diarrhea, hematochezia 83 cases (74.8%), CD mainly abdominal pain in 62 cases (63.9%), fever in 19 cases (19.6%) most common. Anal fistula in 20 cases (19.6%), perianal abscess in 9 cases (9.3%), intestinal obstruction in 13 cases (13.4%), Extraintestinal manifestations were arthritis in 6 cases. When colonoscopy, UC's most lesions in the rectosigmoid(24%). Pathology of the crypt abscess (36.9%), goblet cells decreased (27.9%) most common; CD lesions with endoscopic ileocolonic type (34%) were the most common.Lesions were segmental, paving stones and intestinal nodular bulge,stiff/narrow.In UC the detection rate of atypical hyperplasia about polypoid change is 43.5%(10/23); the detection rate of atypical hyperplasia about bowel stiff/narrow is 50%(5/10). Through the variance test, a statistically significant difference (P<0.01). In CD the detection rate of atypical hyperplasia about polypoid change is 15.4%(2/13); the detection rate of atypical hyperplasia about bowel stiff/narrow is 7.7%(2/26).Through the variance test, the difference was not statistically significant (P> 0.05)Conclusion:The diversity of clinical manifestations of inflammatory bowel disease, colonoscopy and histological examination confirmed that it is an important tool. Court cases, a low incidence of cancer, ulcerative colitis group of case detection rate of atypical hyperplasia was significantly higher than that of Crohn's patient group. The longer course of ulcerative colitis, colonoscopy performance as polypoid change, bowel stiff/narrow, is the higher incidence of atypical hyperplasia, which needed to attract clinicians attention. We should strengthen endoscopic surveillance about cases obser ved intestinal atypical hyperplasia group of inflammatory bowel disease, the establishment of follow-up system and improve the discovery of early cancer.