A Clinical Study On The Treating Renal Damage Due To Primary Hypertension With Lianhuang Turbid Decoction

Objective:. To study the effect of Lianhuang Turbid decoction on renal structure and explore its mechanism. Methods: 60patients with RDHRFS were divided randomly into two groups with theratio of 1∶1,the experiment group and the control group.Patients. In the experiment group(30cases),patients were administered orally with LHCTG,while those in the control group(30cases) were treated with Uremic Clearance Granules(UCG). Besides the general treatment, LianHangJiangZhuo decoction is given to experimental group (1 package once, 2 times daily) and Niao Du Qing Granule for control group with a treatment of at least 12 months. Patients in both groups are observed with blood pressure, 24-hours urinary protein, hemoglobin and serum creatinine changes, observe their renal dysfunction development trends by analyzing the countdown through the serum creatinine (1/Scr) and time of regression coefficient and linear regression and the direction of slope b values and analyze the influences hypertension, Proteinuria, and hemoglobin on the value of b. Results: After the treatment, the b value of control group is -8.64×10^-4 and-5.79×10^-4 of experimental group, which is apparently smaller than control group (P<0.01). It shows that Lian Huang Jiang Zhuo decoction has a better therapeutic effect than Niao Du Qing Granule on relieving RDHRFS. According to the observation of the influences which hypertension, proteinuria, hemoglobin and PTH are on RDHFS, it is find that these factors accelerates deterioration of CRF and herbal medicine interferes the influence these factors are on CRF and Lian Huang Jiang Zhuo decoction is better than Niao Du Qing Granule in relieving CRF (p<0.05).Conclusion: Applying the method of Qu Shi Jiang Zhuo,Jian Pi Bu Shen and Huo Xue Tong Luo (Qu Du Granule) relieves RDHRFS by relieving hypertension, proteinuria, anemia, etc.