Clinical Significance Of Scc-ag,cea And CA19-9 In Serum Test In Esophageal Squamous Cell Carcinoma

Objective To explore the clinical practice value of serum SCC-Ag, CEA and CA19-9 in diagnosing esophageal squamous cell carcinoma (ESCC).Methods 50 patients with esophageal squamous cell carcinoma and not treated by surgery and 30 esophagitis patients diagnosesd by gastroscope inspection and pathological biopsy at the same time were selected as study group and control group. SCC-Ag, CEA and CA19-9 levels in serum among 50 patients with esophageal squamous cell carcinoma and 30 patients control group with esophagitis were measured by electrochemiluminescence immunoassay(ECLIA), and their levels were compared and analyzed.Results (1) The results showed that the serum SCC-Ag, CEA and CA19-9 levels in esophageal squamous cell carcinoma were significantly higher than that in esophagitis group (P<0.05). (2) The levels of serum SCC-Ag, CEA and CA19-9 in esophageal squamous cell carcinoma with differentiation grade weren't significant (P>0.05). (3) The positive rate of SCC-Ag in patients with esophageal squamous cell carcinoma was 46%, which was higher than CEA(16%) and CA19-9(26%), SCC-Ag was significant statistically compared with CEA and CA19-9(P<0.05), CEA wasn't significant statistically compared with CA19-9(P>0.05). (4) The positive rate of SCC-Ag was significant statistically compared with study group and control group(P<0.005). (5) The positive rate of three markers combined together was 64%, which was higher than any single detection. The positive rate of concurrent three markers was higher than SCC-Ag, but was not found significant difference (P>0.05), The positive rate of concurrent three markers was higher than CA19-9 and CEA, which was statistically significant(P<0.05).Conclusions The positive rate among the three tumor markers where as SCC-Ag was the highest, CEA and CA19-9 were lower, serum SCC-Ag could be the reliable markers for diagnosing esophageal squamous cell carcinoma; The combined detection of three markers may increase the positive rate than any single marker.