The Clinical Retrospective Analysis Of Deep Venous Thrombosis In The Lower Extremities

Objective To evaluate the risk factors and clinical characteristics of deep venous thromboembolism(DVT) of the lower extremities, to investigate the risk biomarkers of idiopathic DVT, to direct the prevention and the therapy of DVT.Method The clinical manifestations and risk factors in 187 DVT patients diagnosed by color doppler ultrasound were retrospectively studied between April 2007 and September 2009.Results The difference of the gender was not statistically significant (P=0.584). The left lower extremity was more frequently involved (P<0.001), and the whole limb type made up 66%. 67.29%DVT patients had Pulmonary embolism (PE), and secondary PE often were associated with DVT of the right lower extremity(P=0.006).86.63%DVT patients had identified risk factors including age over 50 years old (60.96%), surgery or trauma(20.32%), cancer(18.72%), immobilization(9.10%), pregnancy and the puerperium(4.28%). Idiopathic DVT patients made up 13.37% of all DVT patients. DVT patients with high level of plasma total homocysteine made up 65.24%.8.02% DVT patients had positive anti-cardiolipin antibody (ACL),32.62% DVT patients had positive anti-beta2-glycoprotein antibodies IgG.Conclusions The deep venous thrombosis of lower extrimities is clinically common illness. The left lower extremity is more frequently involved and the whole limb type is dominant. The most common risk factors are age≥50, surgery or trauma, cancer, immobilization, pregnancy and the puerperium. Hyperhomocysteinaemia is a new and important risk factor for DVT. Anticardiolipin antibodies, anti-beta2-glycoprotein antibodies may be the correlation factors of DVT. So, for the secondary DVT, the therapy of protopathy is necessary besides traditional treatment, including anticoagulation and thrombolysis, but for the idiopathic DVT, detecting the etiological factor and enforcing the associated treatment is of significance.