Study Of Functional Mri In Motor Aphasia After Ischemic Stroke

Objective To investigate the changes of the functional areas of language and its clinical value by using functional magnetic resonance imaging (fMRI) of 3.0 Tesla in motor aphasia after ischemic stroke.Material and Methods MR data of heads were collected in 12 patients with motor aphasia after ischemic stroke and 11 healthy volunteers. Conventional MR scanning and BOLD- fMRI examination of heads were carried out using a 3.0 T superconduc- tive magnetic resonance imaging system.Word-association test based on block design task and statistical parametric mapping( SPM5) were used for data processing and an- alysis. The language functional damage of lesion group were observed and compared lesion group with control group about differences of brain activation and laterality in- dex using SPSS 16.0 statistical software for analysis.Results The task design in this study for language research has good specificity and reliability. Normal subjects'major activations were:left inferior frontal gyrus(BA44 /45 /47),the bilateral superior and middle frontal gyrus,bilateral supplemental motor area(SMA),bilateral parietal cortex(BA7/40),bilateral occipital cortex(BA17/18/19), and left thalamus, right middle temporal gyrus,right temporal lobe fusiform gyrus.the bilateral cerebellar,the major activations had obvious advantages hemispheric lateralization feature and there were individual differences.All patients with Broca aphasia can find different degree of activation decreased with language areas,the larger infarction in the same position,the weaken activation the brain,and more serious clinical symptoms.Those involving the Broca's area infarction,were mainly activated bilateral occipital lobe and cerebellar hemisphere,the left language areas had no significant activation,and can't find the right hemisphere compensatory phenomenon. Those involving the left basal ganglia areas infarction,the left inferior frontal language areas were activation decreased,the greater the scope and infarction,the more obvious activation decreased;Those involving the left temporal lobe infarction,the left inferior frontal language areas were also activation decreased,one of them was found the left occipital lobe and left cerebellum activation decreased significantly,the other one who with left temporal and occipital lobe infarction shows activation increase than the normal in bilateral superior and middle frontal gyrus.The number of voxels with bilateral cerebral hemispheres and bilateral frontal lobe between case group and control group were both statistically significant (P <0.05);The LI value between case group and control group was no statistically significant (P > 0.05).Conclusion As an effective method in the study of motor aphasia after cerebral infarction in vivo,blood oxygenation level dependent functional magnetic resonance imaging,through the analyses after measurement of brain activation with the task of language can provide functional anatomy and quantitative basis for pathogenesis, rehabilitation programs and prognosis of motor aphasia after ischemic stroke. Key words Magnetic resonance imaging; Blood oxygenation-level dependent;...