Protective Effects Of Lycopene On Aortic And Liver In Hyperlipidemia Rats

Objective:To research the effects of lycopene on aortic and liver in hyperlipidemia rats; to provide the evidence for the exploitation of lycopene and utilizion in body and research further.Methods:64 male SD rats were divided into eight groups:a control group, a hyperlipidemia group, a fluvastatin sodium group,5 lycopene groups with the dose at 4.4,11,22,44,110 mg·kg-1·bw-1·d-1.Referring to Deepa's means, the hyperlipidemia model was formed. The experimental period lasted 3 weeks, and serum TC, TG, HDL-C, LDL-C, SOD and MDA were texted during the experiment. At the end of experimental, hepatic TC, TG, LDL-C, SOD, MDA, LPL, HL and VEGF levels were texted. The pathological changes of aorta and liver were observed under microscope.Results:①In hyperlipidemia model, serum and live hepatic lipid were significantly higher than the other groups. Aortic lumen irregular, intima was significantly thicker, and a large number of foam cells accumulated in the intima and subintimal. The board cable structure of liver disappeared, and there were a large number of lipid deposition cells in the liver and lymphocytes around vascular. ②Compared with model group, serum TC, TG, LDL-C, MDA, AI and AIP were lower, SOD activity being enhanced, and the accumulation of foam cells reduced in fluvastatin sodium group and lycopene groups in varying degrees. The lycopene group with the dose at 44 mg·kg-1·bw-1·d-1 of had the most obvious effect.③Compared with model group, hepatic TC, TG, LDL-C, MDA, VEGF levels were lower, SOD, LPL, HL activity being enhanced, and inflammation and liver fatty change also mitigated in fluvastatin sodium group and lycopene group in varying degrees. The lycopene group with the dose at 44 mg·kg-1·bw-1·d-1 of had the most obvious effect.④Taken the absolute values as the dependent variables, which equaled serum and hepatic indicators in lycopene groups minus those in the model group, and taken the lycopene doses as independent variables, there would be 14 curves.Conclusions:①Deepa method model took less time, and the result was evident to build hyperlipidemia.②Besides reducing blood lipids, Lycopene enhanced the body's antioxidant capacity to result in protecting the aortic.③Lycopene reduced hepatic lipid and peroxidation by regulating the activity of lipid metabolism enzymes and enhancing antioxidant capacity, and regulates the VEGF levels to prevent the inflammatory response from expanding, resulting in protecting the liver cells and liver blood vessels.④With curve fitting, there can be aware of the changing level about serum and hepatic indicators at the range of lycopene doses at 4.4～110 mg·kg-1·bw-1·d-1...