Body Transdermal Delivery Of Lidocaine Delivery Preparation And Experimental Research

Objective:To screen lidocaine to be prepared to pass the best ratio of drugs. Orthogonal test to optimize the delivery of lidocaine body volume ratio of drug to encapsulation efficiency and drug loading, as the indexes, using L9(34) Orthogonal optimization of lidocaine transfersomes prescription. Preparation of lidocaine hydrochloride with the best prescription to pass physical solvent, and its physical and chemical properties evaluated.Methods:neat levels-factors that indicator to pass physical tests on the lidocaine overall design, comprehensive comparison, statistical analysis, to achieve through a few number of experiments to find a better production conditions, in order to achieve the maximum effect of production processes. Orthogonal test to optimize the delivery of lidocaine body volume ratio of drug to encapsulation efficiency and drug loading, as the indexes, using L9(34) Orthogonal optimization of lidocaine transfersomes prescription. This can be a key factor in this experiment the change in equilibrium within the sample, so that each trial has a strong representation, due to orthogonal dispersion characteristics of a balanced to ensure a comprehensive test some of the requirements of these trials are often better able or better to achieve the purpose of experimental study. Use of Thin Films-Preparation of Lidocaine in ultrasound transmission body solvent. Fluorescence microscope lidocaine hydrochloride delivery body shape, with the Malvern laser particle size analyzer to monitor delivery of lidocaine body of the solvent particle size distribution, high performance liquid chromatography of lidocaine hydrochloride concentration and determination of solution recovery rate. Chromatography determination of glucose solution with the entrapment efficiency, and through different periods of drug entrapment efficiency of testing laboratories to study its stability.Results:The body of lidocaine delivered the best combination of prescription A2B3C1D2 that lecithin:cholesterol 2:1; lecithin:lidocaine 3:1; methanol:chloroform,1:1; ultrasonic time of 10 min. Square ratio to be used here to pass physical solvent lidocaine hydrochloride particle size was 81.1 measured soil 3.1nm; recovery was 100.2%±0.35%(n=3); encapsulation efficiency was 82.5%±1.85%(n=5), solution should be placed in 4℃refrigerator to save.Conclusion:After delivery of lidocaine with orthogonal body gets prescription drugs in the ratio of the best quality, the drug loading appropriate to the size of medium, good stability, be able to transfer body after the transdermal delivery of lidocaine to provide vitro. Lidocaine hydrochloride preparation process to pass a viable body of solvent recovery, encapsulation efficiency and good stability.