| Titanium has good biocompatibility and excellent mechanical properties, and titanium was widely used in biomedical manufacturing of medical equipment. However, in clinical practice, titanium grafting material in some cases faced many problems, such as loosening, infection, needing for local drug treatment. So, the combination of drugs and devices provided for these problems may be the choice.In order to explore the effective combination of drugs and devices, the focus of this paper is how to make tianium dioxide nanotubes as a drug carrier, controlling the release of the drugs, and use a new approach for effective control of drug release by coating a hydrogel surface on that carrier. This whole process of the preparation process was studied using field emission scanning electron microscopy, Fourier transform infrared spectrophotometer, UV spectrophotometer, and the contact angle instrument on the experiment involving the drug carrier, drug delivery, etc. and their characterization and optimization to in-depth study and prove the feasibility of drug delivery systems. Full-text includes the following three specific research:①Titania nanotube: by classical electrochemical anodic oxidation method, we have successfully prepared titania nanotube arrays. First, we turn to the first generation of nano-tubes (mainly hydrogen fluoride HF as the electrolyte), the second generation of nanotubes (mainly potassium fluoride KF, sodium fluoride NaF as electrolyte), and the third generation of nano-tubes (mainly ammonium fluoride NH4F as electrolyte) studied by the experiment required nanotube. Then, how to fabricate nanotube diameter gradient on the same titanium plate was studied. We used field emission scanning electron microscope (FESEM) to all samples optimized and characterized. Results show that we found some desired experimental titanium dioxide nano-tube structure, which provided a carrier for the experiment.②Grafted silane coupling agent (MPS) on titania nanotubes , preparation of hydrogel films and the drug release: titania nanotubes after the mixing treatment for MPS made it grafted onto the surface with hydroxyl end of nanotubes due to physical adsorption, and thus grafting effect reached. In order to control the hydrogel lower critical solution temperature (LCST) to the physiological temperature of 38℃, the experiment in the traditional isopropylacrylamide (NIPAAm) system, the addition of acrylamide (AAm), was synthesized by LCST temperature 38℃hydrogel network results. We use the spin-coater to dropping gum onto it as the method of synthesis of hydrogel carrier surface.We used Fourier transform infrared spectrophotometer (FTIR), UV spectrophotometer (UV) and field emission scanning electron microscope (FESEM) to demonstrate that silane coupling agent MPS, and hydrogel grafted well, and the drug release curve illustrates the experimental preparation of the feasibility of drug delivery systems.③Chitosan / DNA complex: the chitosan and DNA fractions of different molar ratio according to different groups, using of chitosan and DNA itself with a different electronegativity to self-assemble process, gained different sizes of chitosan / DNA complex particles. ZETA potential by particle size analysis instrument function was about 200-1700nm particle size, showing that micro-nano-particles prepared by this stage having possibility of as-carried drug.The thesis statement of the titania nanotubes by chemical modification of the physical surface temperature sensitive drug delivery system may be of specific steps and methods and to explore the subject on the basis of the titanium dioxide nanotubes and other drug molecules feasibility of the application.
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