The Expression Of CD24 In Colorectal Polyps

Objective:To reveal the role of CD24 in the canceration of colorectal adenomas and provide theoretical basis for the prevention and treatment of colorectal cancer. Methods:CD24 and P53 expression were examined by immunohistochemical staining in 64 colorectal adenomas, including 21 mild dysplasia,21 moderate dysplasia,21 severe dysplasia, which had been removed by endoscopic biopsy, surgical resection and polypectomy in our hospital between September 2007 and September 2009. We also collected 20 polyps whose diameter were less than 1.0 cm, 17 polyps whose diameter between 1.1 cm and 1.9 cm, and 22 polyps whose diameter were more than 2.0 cm. polyps were collected, including 14 single polyps,19 multiple polyps,20 rectal polyps,22 left colon polyps,22 right colon polyps. In the comparing groups, we collected 20 inflammatory polyps,20 normal colonic mucosal tissues, and 22 adenocarcinoma. Trough immunohistochemistry, the expression of CD24 and p53 were observed in different histological types, abnormal dysplasia of different levels, different sizes, different number and different parts of colon. Results:CD24 and p53 expression were not observed in normal mucosa and non-adenomatous polyps, but it was higher in villous adenoma; It was increased significantly in severe dysplasia and adenocarcinoma. Their expression were related with histological type and degree of dysplasia (P<0.05). CD24 expression between normal mucosa and adenomas, adenomas and adenocarcinomas were statistically significant (P<0.05).CD24 expression between normal mucosal and mild dysplasia were statistically significant (P<0.05), but p53 expression among normal mucosal, mild dysplasia and moderate dysplasia were no statistically significant (P>0.05). The difference of p53 expression in different sizes was no significant difference.But the CD24 expression was statistically significant (P<0.05) between polyps which were smaller than 1.0 cm and bigger than 2.0 cm. The differences of CD24 and p53 expression between single polyps and multiple polyps were statistically significant, however, were no significant difference among different parts of colon. Conclusion:These results suggest that increased CD24 and p53 expression may be related to growth and malignant transformation of adenomas, which play an important role in the progression of colorectal adenomatous changes. Comparing with p53, CD24 may be better for detecting the possibility of malignancy in polyps.