Change Of The Nitric Oxide, Noradrenaline And Endotheline Before And After The Coronary Artery Stent Implantation In Patients With Unstable Angina

Coronary heart disease is one of the most familiar and multifocal disease. Being a mainly part of Coronary heart disease, unstable angina pectoris often grows to be acute myocardial infarction or sudden death. Percutenous transluminal coronan, angioplasty(PTCA) and the stent implantation is one of the most efficacious way to cure it. But some complications, such as acute vasospasm. subacute thrombosis and intrastenl restenosis have badly effected the treament, also its causation is still unknown. In recent years, being to the achievement of biological research, there is some further understanding to the biological base which cause the complications after the the coronary arter\ stent implantation and unstable angina. So it has important significance to the preventing of unstable angina and the guidance of unstable angina treatment by studying tne causation and its correlative factors.By histological analysing of stent implanted vascular, it shows that the most important parts of restenosis including: thrombosis, inflammatory cell, smooth muscle cell, and so on. Some studies make know that activation and the adhension of blood platelet are the causation of complications above-mentioned. Nitric Oxide, namely EDRF, can restrain the adhension of blood platelet, maintain the blood platelet to be in a no-adhension stead\ state.and can prevent the form of thrombosis.NA can promote the adhension of platelet. CT is the vascular active substance which has the most forceful shrink effect excreting b\ the vscular endothelium. And it can promote the proliferation of vascular smooth muscle cell. This experiment study the possible relationship between complications and the change of NO, NA and ET before and after the coronary artery sent implantantion.- 5 -Meathod:In 25 patients with coronary form Aug, 2000 to Dec 2000,blood samples were drawn from cornoary sinus before and instanter,3h 6h arter PTCA and stents. Measure the content of NO, NA and ET in blood plasma by method of colorimetry, HPLC and unbalance irradiation immunoassay. Results: 1 .Change of NO before and after PTCA and stents: there is a decrease of NO after PTCAand stents (p<0.05). 2.Change of NA before and after PTCA and stents: instanter after PTCA and stents. there isan increase(p<0.05);3h and 6h, there are no change(p>0.05) 3.Change of ET before and after PTCA and stents: instanter and 3h after PTCA and stents.there is no change (p>0.05); 6h, there are is an increase(p<0.05). 4.Change of ET/NO before and after PTCA and stents: instanter after PTCA and stents.there is an increase (p<0.05);3h and 6h, there are no change(p>0.05). Conclusion:1 .There is a decrease of NO after PTCA and stems:. 2.There is an increase of NA after PTCA and stents: 3.There is an increase of ET after PTCA and stents:. 4.There is an increase of ET/NO after PTCA and stents:. 5.The change of NO, NA, ET and ET/NO may associate with the adhension of bloodplatelet, the proliferation of vascular smooth muscle cell and acute vasospasm.