Clinical Research On Hepatic Fibrosis Due To Chronic Hepatitis B Treated By Yang Gan Ao Ping Mixt

Objective:Hepatic fibrosis due to chronic hepatitis B is a serious diseasewhich influence people's health. It is the former phase of cirrhosis and the necessary patho-process towards to liver cirrhosis,which is relevant to liver cancer.Hepatic fibrosis is a pathological chang of strut-ural abnormalities and (or) dysfunction of Liver by damaging liver continuity and causing to happen that Extracelluar matrix(ECM), collogen especially,deposit excessively.The constituti-on shows micrangium vascularizition of sinus hepaticus and acini hepatis;The function shows hypohepatia, portal hypertension and so on. It is a key point for various kinds of chronic liver disease that we can intercept and reverse hepatic fibrosis as soon as possible.For this reason,th-e study on prevention and cure of hepatic fibrosis is a hot spot for doctors of traditional Chine-se medicine and medical doctors,who are engaged in the clinical and scientific research about hepatopathy.Notwithstanding there doesn't have the name of hepatic fibrosis in TCM.The comment ca-n be seen in the articles of the correlative diseases, such as jaundice, abdominal mass,carbunc-le on hypochondrium, and so on. Beside the invasion of damp heat and reliquus pathogenic factor, the disease is relevant to emotional disorder and depression of liver-Qi in etiology and pathology. The functional disorder of liver, spleen,kidney (LSK) and qi and blood stagnation because of Qi-blood obstructing and stagnation in liver meridian.The pathological changes is a dynamic state which can transform from sthenia syndrome to deficient syndrome, from qi to blood and meridian.That the disease is inseparable and chronic progress due to damp heat and pestilence.The initiating agent and persistent etiological factors of hepatic fibrosis are damp heat and pestilence,however, damp heat and pestilence gathers at xue fen of liver meridian, which lead to stagnation of blood.The latter provid a favourable environment for amp heat.At last, damp heat, stagnation of blood and pestilence are accumulated, which is the main factor that lead the disease to form and to be aggravated.With comprehending numerous literature about Chronic Hepatitis B,we can draw a conclusion that Chronic Hepatitis B due to damp heat and pestilence,the latter hide in xuefen,which induce qi and blood disorde.Yang Gan Ao Ping mixt(YGAP)can treat Chronic Hepatitis B by clearing away the heat and promoting diuresis,cuting down the inflammation level of hepatic cell and restraining viral replication.Thereby,it can produce a marked effect on anti-virus. Many years' clinical practice favors a satisfying curative effect. Methods:Be brought into case 40 people according to being brought into standard, among them, be cured 20 people of group,be contrasted 20 people of group.It is a elementary treatment that all patients took Lamivudine 0.1g by oral administration once daily.The treatment group were treated by YGAP(yinchen,danggui,danpi,qiancao,fengweicao,sheshecao,chishao,yujin and so on,provided by manufacturing laboratory of Jiangsu Provincial Hospital of Traditional Chinese Medicine)and took it for half a year.the control group were treated by elementary treatment whithout traditional Chinese medicine.These hereinafter manifestations of the patients were observed synthetically:clinical symptoms, signs (abdominal distention,asitia,bitter and sticking taste of mouth,flavo-urine,anorexia),indexes of the liver function (ALT,AST,ALB,GLB,GGT,ALP,A/G),signs of HBV (HBsAg,anti-HBs,HBeAg,anti-HBe,anti-HBc,HBV-DNA.),indexes of hepatic fibrosis (PCâ…¢,â…£-C,HA).Result:The following are the results of the treatments.(1)After 6 months' treatments, the ratio of significant clinical curative effects in treatment and control groups attained 95% and 50% respectively. Both of the two formula could meliorate clinical symptoms and the liver function, and reduced the excessive precollagenâ…¢(PCâ…¢),collagenâ…£(â…£-C) in serum, Contrasted to the control groups, the degree of melioration in the treatment groups was better,(P<0.05).(2)After 6 months' treatments, the ratios of becoming negative of HBsAg and HbeAg in both groups were 0%-0% and 9.0%-8.3%.There was a significant difference between two groups of the negative of HBeAg.Conclusion:a higher curative effect in treating hepatic fibrosis due to chronic hepatitis B, and it restrained the development of the disease in a certain degree.