| BackgroundHigh intensity focused ultrasound (High Intensity Focused Ultrasound, HIFU) is a new non-invasive therapy, as early as 40 years in the 20th century, foreign scholars had the idea of giving the patients non-invasive surgery with HIFU , then another expert for the treatment of central nervous system in experimental research, but effective in real-time experiment in the effect of the lack of direct control means to restrict the development of this technology. After 70 years, some scholars has tried to use the temperature thermocouple needles into the target area [1], ultrasound imaging, CT and magnetic resonance imaging (MRI), ultrasound elasticity imaging and HIFU treatment of IBS imaging technology for the implementation of effective evaluation But there are disadvantages of each method. Current clinical efficacy of HIFU treatment evaluation of the implementation of the most important means of ultrasonic gray scale monitor, but the use of gray scale ultrasound monitoring, there is coagulation necrosis occurred, but can not see the gray change, directly affecting the implementation of efficacy of HIFU treatment evaluation. In this study, fresh bovine liver in vitro experimental study, based on ultrasound images of multi-resolution analysis method HIFU therapy more effective implementation of the efficacy evaluationObjectiveMulti-resolution of the texture parameters of HIFU induced tissue coagulation necrosis evaluation, trying to establish a sensitive and accurate of the HIFU induced tissue coagulation necrosis of the evaluation methods, making HIFU treatment in the clinical evaluation of the process to achieve real-time effects more accurate and sensitive.Materials and Methods1.1 Research object: Fresh isolated bovine liver (slaughtered within 6 hours)1.2 Experimental Equipment: The JC model focused ultrasound tumor therapy system, the frequency of treatment of head and 0.9MHz, focal length 150mm. On irradiated beef liver, the use of pre-designed irradiation parameters were fixed in ultrasound-guided irradiation.1.3 Test method steps:1.3.1 each organization receiving HIFU irradiation and ultrasound irradiation before the gray image archive, after receiving different ultrasonic irradiation time and the gray image archive. Preparation of observation.1.3.2 the acquisition of ultrasound images using Matlab6.5 software interception area of interest, the two transform the image of each piece of the original image generated nine represent different frequency and resolution of images, making the naked eye can not distinguish between the original The subtle texture visible.1.3.3 will be stored in Excel get through the second wavelet multi-resolution of the texture parameters of data entry weak3.6 SVM toolbox software, through the training of classification decisions obtained hyperplane. And to the standard classification decision hyperplane, with the remaining samples as a testing set for classification and discrimination, to validate its robustness.1.3.4 using ROC curve to evaluate the test results determine their accuracy. 1.3.5 The results were statistically analyzed using SPSS12 software.Result1 The diagnostic sensitivity of Fall for the ex vivo liver after receiving HIFU irradiation was 86.96%.2 The diagnostic sensitivity of F3 for the ex vivo liver after receiving HIFU irradiation was 70.97%.3 The diagnostic sensitivity of G3min for the ex vivo liver after receiving HIFU irradiation was 23.19%.4 The diagnostic sensitivity of Gj for the ex vivo liver after receiving HIFU irradiation was 52.22%.5 ROC curve area for F3 and Fall wereAF3 = 0.79, AFall = 0.81. 6ROC curve area for G3minand Gj were AG3min = 0.54, AGj = 0.67.ConclusionUnder the multi-resolution texture parameters on the HIFU irrelevant due to fresh bovine liver tissue coagulation necrosis of the judge is feasible, and high sensitivity, using ROC curves verify the accuracy of diagnosis, Fall, and Fl the two parameters under the ROC curve area 0.81 and 0.79, respectively, said the diagnostic accuracy rate of the middle class. |
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