Study On Antagonism Of Sanjiao Fuzheng Mixture 1, 2 To Side Effects Of Radiotherapy And Chemotherapy In Mice

Objective: To observe the antagonism of Sanjiao Fuzheng Mixture 1, 2 in mice to radiotherapy and chemotherapy-induced bone marrow suppression and low immune function.Methods: low white blood cell and immune suppression model in mice were established, Fufang A Jiao Jiang, levamisole hydrochloride tablets (LMS) as a positive control, respectively; high, medium and low dose were set up ,determination the peripheral leukocyte count, bone marrow nucleated cells, spleen colony-forming units (CFU-S) and carbon clearance ability to study each group's effect and the best dosage. acute toxicitywas studied by Mice orally administered.Results:The Sanjiao Fuzheng Mixture 1, 2 and Fufang A Jiao Jiang have the functions of upgrading peripheral leukocytes, and promoting the value of bone marrow nucleated cells and CFU-S, and enhancing reticuloendothelial system phagocytic function in mice of low immune function ,and the Mixture 1 is the best one; no significant difference was observed of the Sanjiao Fuzheng Mixture 1, 2 and levamisole hydrochloride tablets on improving reticuloendothelial system function in mice ;the middle dose is close to the best one. MTD of mice to 150 g / kg body weight.Conclusion: The Sanjiao Fuzheng mixture can be used to radiotherapy and chemotherapy- induced bone marrow suppression and low immune function, safe And non-toxic side effects,and lay the foundation for clinical.