Elevated Plasma Thrombomodulin And D-Dimer Level In Patients With Sleep Apnea Syndrome

Objective: To investigate the damage of in vascular endothelium and activation coagulation– fibrinolysis systems in sleep apnea syndrome(SAS).Methods: 15 subjects without SAS and cerebrovascular disease (CVD) were randomly selected as the control group,30patients with SAS were recruited as the SAS group ,which was further divided into two subgroups , CVD subgroup (16 patients) and non-CVD subgroup ( 14 patients ) . The changes in plasma concentrations of TM and D-D were tested by Elisa and SimpliRed.Results: Compared with control group, the SAS group had significantly higher TM and D-D levels . The prevalence of CVD in SAS group was 53.3 %(16/30). TM and D-dimer were higher in SAS group than control group. Such differences were more significant between control group and CVD SAS subgroup ( P < 0. 05) .There were no difference in TM levels between Non-CVD SAS group, but D-D level increased significantly ( P < 0. 05) .Pearson annalysis indicated that TM'correlation with apnea hyponea index and oxygen desaturation index is irrelevant. Moreover, D-dimer has no correlation witn Apnea hyponea index and oxygen desaturation index.Conclusion: There was a higher incidence of CVD in SAS. Vascular endothelial function and coagulation– fibrinolysis systems were significantly impaired in patients with SAS, Which may be one of the causes of complicated CVD in SAS patients.