The Effect Of Alendronate In Bone Mineral Density Postmenopausal Women

Objective:To investigate the bone mineral density(BMD) in the communityof Xi'an and know the skeletal health condition of postmenopausal womenthrough selecting 140 postmenopausal women and provide the basis forprevention and treatment. Pick 80 patients from above 140 patients according tothe chosen standard, To investigate variation of the bone mineral density(BMD)and bone resorption index in treating reduced bone mineral density ofpostmenopausal women through Different doses of Alendronate and Calcium,andthus to study whether they have the same effect.Method:The BMDs of 140postmenopausal women of different age group in the community of Xi'an weremeasured using dual energy X―ray absorptiometry(DEXA) . devide 80 victimsinto two groups at random,40 persons each group.After 12 weeks and half a yearand one year,meature the bone mineral density(BMD) and bone resorption index.Results The trend of decrease of BMDs in the age group of 50—60 forpostmenopausal women are faster than other groups , and the trend decreaseslowly in the age group of 60– 70.but there are slight increasing trends after 70s in BMD ,especially lumbar spine .The incident of Osteoporosis increases withaging. After 12 weeks , bone resorption indexes decrease;After half a year and oneyear, the bone mineral density increase. ConclusionConclusions The trend of decrease ofBMDs are different in all kinds of groups, The prevalence of osteoporosisincreases with age. BMDs in the age group of 50 - 60 for postmenopausal womendecrease obviously,so a intervention is necessary. the low doses of Alendronateand Calcium have the same effect with the common doses,so it is feasible to usethe low dose of medicine instead of the common dose of medcine...