Effects Of Atorvastatin And Fluvastatin On Blood Levels Of Blood-serum Inflammatory Cytokines And Lipids In Patients With Unstable Angina Undergoing Percutaneous Coronary Intervention

Background:Percutaneous transluminal coronary intervention (PCI) can lighten blood vessel occlusion,improve bloodstream of aeteria coronaria,release CHD myoc-ardial ischemia,it is very common using in clinic at present.Because of PCI development fastly,Restenosis after the operation is more and more to be followed at present,the widespread viewpoint thinking is correlated to inflammatory reaction after PCI,newborn inner film accrementition,ground substance degradation increase.In recent years study and research discovering, for long time taking statins it can't only degrade lipids,but also can accommodate inflammatory reaction stabilizating plaque,reducing the risk of the plaque rupture, decreasing the risk of the frame restenosis.Atorvastatin and fluvastatin are very common use in clinic,this article through con-trast atorvastatin and fluvastatin curing UA Patient's hs-CRP, MMP-9,IL-18 and lipids concentration changing before and after PCI,contrast the adverse effect incidence between two medecines include (indigestion,nausea,headache,stomachache,liver fun-ction ubnormality etc),record acute aeteria coronaria events incidence (unfatal myo-cardial infarction,heart failure,stroke,PCI/CABG,rehospit alization,cardiac and uncar-diac death),Approaching two statins' degrade bloodfat,depress inflammation and security.Methods:We collect 2008 December to 2009 July130 UA patients in affiliated hospital of jining medical college did the PCI as objects,They all correspond international Society of Cardiology and World Health Organization ischemic heart disease standard.We reject the cases below these conditions:tumor,trauma,endocrine secretion disesae.Nearly one week who take the medecine antibiotic,glucocorticost-eroid and in four week take stains.There identify acute chronicity inflammation,mali-gnant tumor,liver ailment or nephrosis.Taking inflammation inhibition medicine,stero id and opium medicine.I assigns them two groups, each group has 65 patients.Atorv-astatin group:on the capital cure include(anticoagul ation,β-block,ACEI and CCB etc) add atorvastatin 10mg everyday,healing 6 weeks.fluvastatin:on the capital cure (same as above) add fluvastatin 40mg everyday, healing 6 weeks.We collected empty stomach venous blood,admission 24h,after operation 24h,healing 6 weeks,determin hs-CRP,MMP-9,IL-18,TC,TG,LDL-C,HDL-C concentration.collected blood 5ml,4℃ 3000run/min condition centrifuging 10 minutes, blood serum preserving-80℃refrige-rator.MMP-9,IL-18,hs-CRP adopt ELISA determining blood serum concentration,T C,TG,LDL-C,HDL-C are determined by inspection department.All data input adopt SPSS13.Ostatistics software to statistics analysis,P<0.05has statistical significanc.Results:①Unstable angina patients after PCI 24h,hs-CRP,MMP-9,IL-18 are all advancing,6 weeks follow-up,atorvastatin and fluvastatin all can degrad inflammatory cytokines contribution,between two groups there do not have obviously different (P>0.05).②The research is to study patients admission 24h,after operation 24h,healing 6 weeks,healing 6 weeks,we can see TC, TG,LD L-C,HDL-C contribut-ion changing,two stains all can degrade TC,TG,LDL-C contribution,but fluvastatin degrade TC,LDL-C action more obviously (P<0.05),but degrade TG two groups comparison have no statistics meaning (P>0.05),observing two medcine elevating HDL-C action,we can see fluvastatin have more action (P<0.05).③6 weeks follow-up two medicine correlation untoward reaction including incidence, atorvastatin group occurr one patient with gastrointestinal tract symptom (1.54%), seven patients confronted abnormal liver function (10.08%), fluvastatin group have six patients occurded gastrointestinal tract symptom (9.23%),one person occurred liver function (1.54%).Two groups all have no patient geted headache,cacesthesia,muscle pain,we can find fluvastatin group gastrointest-inal tract symptom was more than atorvastatin group (P<0.05).we also see atorvastatin group liver function patients were more than another group.We overview record six weeks acute coronary eventincidence have no statistics meaning (P>0.05)Conclusion:①After PCI hs-CRP,MMP-9,IL-18concentration advancing,6 week-s after two groups degrade inflammatory cytokines above-mentioned action all strong.②Two groups display the same good security after PCI,it can degrade untoward eve-nt use these medicine risk.③This study supports if there have no contraindicati on,we should give the patients statins as early as we can after PCI.