The Study On The Treatments For Helicobacter Pylori Eradication With Traditional Chinese Medicine And Antibiotic

Objective:To eradicate Xiangsha Liujun pills by combination of Chinese patent medicine Xiangsha Liujun pills and antibiotics to HP. To evaluate the effectiveness of the combination method on the HP eradication and reducing antibiotics'adverse effects based on the clinical observation by comparison with the single antibiotic method.Methods:1.Selected 60 patients, who met the inclusion criteria, took their score before and after one-week treatment according to the adverse reactions and other symptoms,4 to 5 weeks later, the patients received 14C-urea breath test (UBT) to detect Hp, defined negative as Hperadication.2.The cases were randomly divided into treatment and control group,30 patients each. There's no significant difference in age, gender and total score of TCM symptom before treatment between two groups.The study were comparable (P>0.05).3.The treatment group were treated by triple therapy in combination with Xiangsha Liujun pills, specifically for the omeprazole 20 mg + clarithromycin 500 mg + amoxicillin 1000 mg,2 times a day, taken 1 h before meals for 7 days by the addition of patent Chinese medicines Xiangsha Liujun pills, eight each time, three times a day. Control group treated with omeprazole alone 20 mg + clarithromycin 500 mg + amoxicillin 1000 mg,2 times a day, taken 1 h before meals for 7 days. Treatment group and control group took one-week continuous medication as a course in absence of any anti-Hp therapy before the evaluation. Record the changes in symptoms and adverse drug reactions during treatment.4. Observe the curative effect and compare the total symptom score changes and symptom scores before and after treatment respectively, and make a comprehensive assessment of Hp eradication rate.5.Statistical analysis:Apply SPSS16.0 statistical software for analysis.Analyze level data by Ridit,analyze count data by X2 test, measurement data were analyzed by t test.Results:1.The clinical symptom scores before and after of the treatment group and control group were treated by statistical analysis (t test), and there was no significant difference.For treatment group, there was no significant difference in clinical symptoms before and after the treatment (P >0.05).But in the control group after treatment, the symptoms got even worse(P<0.01).The results of the two groups after treatment were statistically analyzed (t test), improvement of abdominal discomfort, nausea/vomiting, poor appetite, tongue coating in the treatment group was better than that in the control group.2.All enrolled patients received the 14C-urea breath test 30 days after the treatment, HP eradication rates were 96.7%,90.0%. By X2 test, HP eradication rate had no significant differences between two groups (X2= 0.268,P>0.05).Conclusion:Eradication of HP in the treatment group is the almost the same as that inthe control group, rather, the combination method improve the symptom, like stomach pain, stomach discomfort, nausea, vomiting, abdominal pain, diarrhea, greasy fur slippery pulse during the process of triple therapy. The combination of Xiangsha Liujun pills and antibiotic triple therapy, not only has no affect on the Hp eradication rate, but also reduce gastrointestinal adverse reactions, improve patient's tolerance, and help improve efficacy.