The TCM Syndrome Differentiation Hormone In Advanced Diabetic Nephropathy

Objective:Diabetes mellitus(DM)of the most common chronic micro vascular complic-ation of diabetic nephropathy(DN), is also the leading cause of end-stage renal failure. Western difficult to achieve so far delayed the purpose of the development process of diabetic nephropathy. DN of traditional Chinese medicine on syndrome differentiation still exist are not standardized, syndrome differentiation of diabetic nephropathy is difficult to reflect its own unique features, the lack of epidemiological studies and many other shortcomings. The purpose of this study is to use the card to observe the differentiation factors of diabetic nephropathy patients with end-stage position, disease distribution and disease-bit sexual, disease resistance and various indicators of the relevance of Western laboratory analysis in order to provide a unified, Differentiation Standard specification to improve effectiveness of Chinese medicine to improve the life of patients with end-stage diabetic nephropathy quality, effective symptom relief, to provide comprehensive and objective of the new theoretical basis.Method:Strictly included in the Second People Hospital, and from Fujian Province, Fuzhou General Hospital of Nanjing Military Region, met the inclusion criteria hemodialysis center hemodialysis patients, case acquisition time from October 2008 to January 2010.Profe-ssor Zhu Wenfeng permit the use of dialectical theory of observation elements with end stage renal disease location, disease and disease-bit sexual differentiation rules, disease resistance and the Western analysis of the relevance of laboratory markers.Result:With end-stage diabetic renal disease entering hemodialysis patients with serum creatinine levels were significantly lower than the control group; parathyroid hormone, phosphorus, cholesterol, BNP and other indicators of diabetic nephropathy was significantly higher than non-diabetic nephropathy group; diabetic nephropathy serum albumin, hemoglob-in and other indicators were significantly lower than non-diabetic nephropathy group; diabetic nephropathy decreased glomerular filtration rate and renal tubular function in the serious extent of the damage than the control group; diabetic nephropathy have appeared in hemodialysis patients left ventricular hypertrophy, and left ventricular remodeling and dominated by concentric hypertrophy, followed by eccentric hypertrophy, concentric remodeling, only a small number of normal.End-stage diabetic nephropathy significant permit spaces to kidney disease mainly, followed by spleen, liver, heart, lung, skin, mind and stomach. End-stage diabetic nephropathy sexually explicit license to qi as a more common disease, followed by blood deficiency, yang and yin, wet, sputum, water stop, tianjin loss, heat, refined losses, qi stagnation, blood stasis; end-stage diabetic nephropathy spaces to heart disease before the card-based, followed by liver, mind, skin, stomach, gallbladder, lung, spleen, table, large intestine.End-stage diabetic nephropathy patients before the certificate of loss with precision as the more common, followed by sputum, cold, heat, qi stagnation, blood stasis, dry, wet, moving wind, outside the wind, the water stop, yang kang, jin loss, yang, yin deficiency, blood heat.Laboratory indicators of the Western position correlation with disease:diabetic nephropathy hemodialysis group and non-diabetic nephropathy and serum creatinine are kidney, spleen and heart were significantly correlated; serum albumin were with the kidney, spleen, significant correlation; hemoglobin and spleen were significantly correlated; plasma fibrinogen were liver and spleen were significantly correlated; BNP and heart were significantly correlated; cholesterol and spleen were significantly correlated.Laboratory indicators of the Western analysis and disease-related:diabetic nephropathy hemodialysis group and non-diabetic nephropathy and serum creatinine were qi deficiency, blood deficiency, yang deficiency, a significant correlation between wet; serum albumin were and qi, blood deficiency have significant correlation; hemoglobin and qi deficiency, blood deficiency significantly correlated; plasma fibrinogen were with qi deficiency, blood deficiency significantly correlated; BNP are and qi, yang and a significant correlation.Conclusion:End stage renal disease syndrome factor differentiation involves bit sick of significantly more than non-diabetic group, it is more related to clinical manifestations, disease location or disease in some elements of evidence points higher than non-diabetic group, so the corresponding symptom severity than non-diabetic group, even more serious. Traditional biochemical and certain disease location, disease has significant correlation. Therefore, the card can accur-ately identify the current prime differentiation disease diseases slip proof factors and disease factors, be objective, standardized, clinical differentiation is the fundamental purpose of the clinical syndrome differentiation has important significance.