Biomechanical Experimental Study Of Seaweed Mixed Adhesive On Bone

Objective:Through observing seaweed mix glue fixation of bone in vitro Biomechanical Research, to further explore whether the seaweed mixed adhesive bonding of bone.Methods:1.Tensile stress test:Take the same size pig femoral cortical bone, were prepared 160 pairs of fracture block, were randomly divided into experimental group and control group 80 and 80 on the right. Experimental group, sodium alginate, sodium carboxymethylcellulose and chondroitin sulfate hybrid gel (experimental glue) adhesive fixed, the control group with sodium alginate and sodium carboxymethyl cellulose mixed plastic (control gel) stick then fixed after the day of the test and were immersed in saline 1,2,3 weeks after the tensile stress intensity and compared.2. Shear experiment:Take the same size pig femoral cortical bone, were prepared 160 pairs of fracture block, were randomly divided into experimental group and control group 80 and 80 on the right. Experimental group was fixed after the experiment Adhesives, Adhesives control group were fixed, respectively, and soaked in physiological saline test day, week 1,2,3 and compare the shear strength.3. Torque experiment:Take the same size pig femoral cortical bone, were prepared 160 pairs of fracture block, were randomly divided into experimental group and control group 80 and 80 on the right. Experimental gel, control gel were applied in the experimental group and control group, the cross section for broken bones broken bones fixed after bonding, respectively, and soaked in physiological saline test day,1,2,3 weeks after the torque and torsion angle.Results:1. Tensile stress test:①sodium alginate, carboxymethyl cellulose sodium and chondroitin sulfate mixed adhesive bonding strength on the day of 17846.13±949.13 Pa, the week 33006.68±3366.57 Pa, two weeks of 24260.18±1756.60 Pa,3 weeks 20978.47±1968.78 Pa; sodium alginate gum and sodium carboxymethyl cellulose mixture of glue on the day of 6321.05±1843.12 Pa, the week 15156.24±2814.28 Pa, two weeks of 9330.00±1723.97Pa, three weeks of 7719.01±631.23Pa. Respectively, on the same day, a week, two weeks, three weeks the experimental group compared with the control group adhesion strength,Differences were statistically significant (P<0.01).②two plastic were fixed within one week to reach a peak and then decline, and the adhesive strength of the experimental group were significantly higher than the control group big. 2. Shear test:test the shear strength of glue on the day of 14455.57±1480.04 Pa, the week was 26358.74±6577.68 Pa, two weeks was 21423.10±6296.82 Pa, three weeks was 18836.13±5637.89 Pa; control gum on the day of 6321.05±1843.12 Pa, week was 5199.64±1773.70 Pa, two weeks to 12334.91±4655.26Pa, three weeks to 7086.99±1300.45Pa. Were on the same day, one week, two weeks, three weeks for the experimental group compared with the control group, shear strength, the differences were statistically significant (P <0.01).②two plastic were fixed within one week to reach a peak and then decline, and the shear strength of the experimental group significantly large compared with the control group.3. Torque experiment:The experiment gum the day of maximum torque 0.12±0.76 N·m, the week 0.19±0.14 N·m, two weeks to 0.15±0.08 N·m, for three weeks to 0.14±0.07 N·m; control gum the day was 0.03±0.02 N·m, the week 0.08±0.05 N·m, two weeks to 0.06±0.03 N·m, for three weeks to 0.05±0.02 N·m. Were on the same day, one week, two weeks, three weeks to reverse the experimental group and control group and the maximum torque angle, the difference was significant (P <0.01).②In the reverse experiment in two plastic maximum torque at fracture blocks are fixed within one week to reach a peak and then decline,The experimental group was significantly large compared with the control group.Conclusions:Sodium alginate, sodium carboxymethyl cellulose and mixed cement ratio of chondroitin sulfate sodium alginate, sodium carboxymethyl cellulose gum mixture significantly enhance the bonding strength, its fixed with calcium chloride can effectively block a certain size of the fracture.