Application Of Raman Spectroscopy In Methamphetamine Detecting

With the development of economy and technology, drug crimes with a increase number have become a topic that cannot be overlooked. Methamphetamine, as a new type of drug, has a specially high abuse. Therefore, it is very significant to detect Methamphetamine accurately and quickly. Also, the requirement to detect the legal case drives the development of criminal scientific technology. One of the significant compositions of criminal scientific technology is the testing of drugs, whose result is a great importance of revelation and verification veneficium and drug pushing,, which plays a decisive role in detection and hearing drug pushing cases. Meanwhile, socialist legal system being improved, the demand of detection and testing is also higher and higher. Thus, it is necessary to adopt modern analysis method and advanced analysis skills to fulfill the analysis of drugs. Raman spectrum analysis technology is an innovation technology that is developed in the recent years, which can provide simple, rapid, reproducible and further more damage free qualitative analysis to the test sample. Also, it needn't do pretreatment to the test sample. The advantages make Raman spectrum analysis technology obtain more and more good graces of researchers. This paper use Raman spectrum analysis technology to do the research of Methamphetamine in mixture. The key content is as follows:(1) Tested the Raman spectrum of Methamphetamine solid powder of 60%rate of purity, soluble starch, saccharobiose, Na2CO3, NaCl and Na2SO4. Then, mixed Methamphetamine with these five compounds with the concentration of 1:1,1:3 and 1:7, and tested these mixtures of different concentrates. Compared with these five compounds without Methamphetamine, the Raman spectrum of the five mixtures showed big changes. There is a strong Raman signal at Raman shift of 1000 cm-1. Also, at 620 cm-1,1018 cm-1, and 1209 cm-1, Raman signal of middle level is appeared. It also appeared a double Raman peak at 1600 cm-1. These Raman characters are same as Methamphetamine solid powder, and Raman characters of these five compounds themselves are overridden. Take 1000cm-1 as an instance, Raman intensity of different concentrates of mixture does not have direct ratio with concentration. However, it has close relationship with the intensity of fluorescence background.(2) Associated with Surface-Enhancement technology, ten common sample drinks in the market were tested by using Raman spectrum. They are Coca Cola, Sprite, Mizone, black tea, green tea, Orange juice, milk, bean milk, milk tea and coffee. These sample drinks are added Methamphetamine. Then, Raman spectrum charts are analyzed and compared between sample drinks without adding Methamphetamine. It was discovery from the research that Raman character signals are seldom showed. Also, the fluorescence background becomes strong with the composition's complication and colors deepen. However. Raman spectrum peaks of sample drinks adding Methamphetamine appear a big change. The fluorescence background became weak and there are apparent Raman peaks at 993 cm-1,1018 cm-1, and 1202 cm-1. Therefore, these three Raman peaks can be used as the identification of whether drinks contain Methamphetamine. Because of each drink has fluorescence background, the accuracy of quantitative analysis is influenced by it. Thus the concentration does not have direct ratio with the intensity of Raman character peaks.(3) Tested Coca Cola, Mizone, Green tea and Orange juice adding and not adding Methamphetamine using Ultra-performance liquid chromatography-Time of Flight Mass technology (UPLC-Q TOF MS). Under the condition of gradient elution, obtained total ion chromatogram and mass spectrum of four groups of solution and Methamphetamine solution. By the analysis of extract ion chromatograms of m/z 150.0966 of these four groups of solution, the chromatogram charts appeared great magnitudes between adding and not adding Methamphetamine. The result of experiment represented that the retain time of Methamphetamine was 1.14min under this experiment condition, and generated m/z 150.0966 ion of high intensity under the positive ion mode, which can be used as a strong verification of whether drinks contain Methamphetamine. The conclusion of Raman spectrum technology is consistent with that of this experiment.(4) Using laser Raman spectroscopy associated with Surface-Enhancement technology detection whether drinks contain Methamphetamine, the result has more advantage: better ruggedness, non-pretreatment, short operation period and user-friendly. It is believed that Raman spectroscopy technology will become a new field for drugs detection with the deep research.