| Diabetes is a disease in which the body does not produce or properly use insulin. As many as 10% of people with diabetes is Type 1 diabetes. Type 1 diabetes is usually diagnosed in children and young adults, and was previously known as juvenile diabetes. Diabetes can damage the kidneys , heart, eyes and skin. At present, the incidence of diabetes are increasing year by year, and it is becoming one of the most common human health problem in the world. Diabetes mellitus is called the third killer following cardiovascular disease and cancer. As a method to treat and prevent diabetes, aerobic exercise has been accepted extensively. The purpose of the present study is to investigate the effect of acute aerobic exercise on insulin , letpin and leptin-receptor in hypothalamus of STZ rats , probing the ameliorate of acute aerobic exercise on adipo-insular axle and the possible central mechanism.In a randomized, 96 male SD rats were divided into 2 groups : diabetes and control. Blood samples were collected after exercise. Insulin and leptin were measured by radioimmunoassay and leptin-receptor expression in hypothalamus were measured by immuohistochemistry.Results: (1) The STZ rats showed low plasma glucose, high insulin and leptin contrasting the control rats. (2) Plasma insulin and leptin were reduced after exercise, but resumed to the control level after 12 hours of exercise.?we fund that plasma insulin and leptin is remarkable positive relevance and plasma insulin and leptin receptor expression in hypothalamus is negative relevance.Conclusion: (1)Acute aerobic exercise can up-regulate insulin sensitive index. (2) Acute aerobic exercise can down-regulate plasma insulin and leptin ,and plasma insulin is the important influence factor for plasma letpin. (3)Acute aerobic exercise have periodic up-regulation effect on hypothalamus leptin-receptor expression during exercise. Therefore we speculate that hypothalamus might regulate adipo-insular axle by adjusting leptin-receptor expression level.
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