Study On The Mechanism Through Which Post-exercise Proteinuria Is Produced By The Rats Doing Intensive Exercise

This article is expected, through the influence of heavy exhaustive swimming sport upon rat Kidney tissue metabolism, to inquire into what parts BLA, Ang II and OFR take in the production of post-exercise proteinuria with a hope it can contribute to the study of the mechanism , through which post-exercise proteinuria is produced, as well as offer concrete evidence for controlling exercise intensity.In this experiment 30 SD rats as experimental objects are randomly divided into 3 groups, with 10 in each group, control group, exercise group and recovery group. Load about 7% of their weights is put on the individuals in latter two groups, then they are made to swim. To make sure to get enough urine, water about 2% of their weights is instilled into their stomaches. The followings are needed to measure in this experiment: 1. the excretion rates of Alb, TP and β2-MG in urine. 2. the activity of SOD and MDA content in the kidney tissue. 3. the concentration of BLA and Ang II in the blood plasma. The experimental results run as follows.1 .The relation between the activity of Ang II and post-exercise proteinuria.The activity of Ang II in the exercise group is conspicuously higher than that in the control group(p<0.01), the recovery group's activity of Ang II is lower than exercise group's, but still higher than the control group's, only without statistical sense(p>0.05). Excretion rates of TP, Alb in the exercise group is higher than those in the control group (p<0.05) , excretion rates of p2-MG also conspicuously higher than those in the control group (p<0.01) . Excretion rates of TP, Alb and β₂-MG in the recovery group is also higher than those in the exercise group (p<0.01) .Through the analysis of correlation, it can also be found that the rise ofAng II activity deeply correlate with excretion rates of Alb, which stand for the permeability of glomerular permeable membrane(in exercise group p<0.01, recovery group p<0.05). Through the analysis of partial correlation, it can also be found that the rise of Ang II activity conspicuously correlate with excretion rates of Alb (PO.01) .2. The relation between OFR changes in the kidney tissue and post-exercise proteinuria.As far as the activity of SOD in the kidney tissue is concerned, the recovery group's or exercise group's is clearly higher than the control group's (p<0.01) , although the recovery group's is higher than the exercise group's, there is no statistical sense (pX).O5) . hi the light of the content of MDA in the kidney tissue, the exercise group's as well as the recovery group's is much higher than the control group's statistically (p<0.01) , though the recovery group's is a bit higher than exercise group's, there is no statistical sense. By the way of correlation analysis, it can be found mat MDA content in the rat kidney tissue correlates with the excretion rate of Alb (PO.05), what is more, MDA content in the recovery group also conspicuously correlate with the excretion rate of P2-MG (P<0.05). Through analysis of partial correlation, it can be found that in the exercise group MDA content clearly correlates with the excretion rate of Alb (PO.05 ) and that in the recovery group MDA content clearly correlates with the excretion rate of P2-MG (PO.01) .3. The relation between BLAand post-exercise proteinuria.In this experiment, comparing with control group and recovery group,exercise group has higher concentration of BLA, what is more , there isstatistical sense. By correlation analysis, it can be clearly seen mat BLAconcentration correlate distinctly with the excretion rates of TP, Alb and fc-MG(PO.05) . Through analysis of partial correlation, it can be found that BLA...