Clinical Experience Of Professor Xu Miao 's Diagnosis And Treatment Of Psoriasis Based On Data Mining

Purpose of the study:At present, psoriasis is considered to be a chronic inflammatory skin disease associated with immunity. Its pathogenesis may be related to T cells. Both at home and abroad have found that the expression of some cytokines associated with T cells in the skin lesions of psoriasis patients is higher than that of healthy people. Based on this understanding, many immunosuppressive agents are used in the treatment of psoriasis. At home,they mostly treat the disease with Acitretin Capsules, Daivonex, Bonalfa, etc., but western medicine has its own limitations in the treatment. In the external use of drugs, the problem of relapsing after stopping the drug can not be solved very well, as well as the side effects. So it is very necessary to seek effective Chinese medicine treatment. Xu xian, the medical director, has long time in medical practice with rich experience in treatment of psoriasis. Therefore, it is very important for us to explore his experience of treatment of psoriasis.Research method:Collect the psoriasis cases treated by professor Xu Xian, Visit time 2009.9-2016.1. A total of 112 patients,192 diagnosis. Using the TCM complex relationship analysis system (liquorice) for data mining. Analyse the overall frequency of administration, the relationship between herb and herb, syndrome types and herb, and the Core herb composition. Count the number of the types of herb, property and flavor, channel tropism.Research production:In 112 patients, male share ratio 58%,female 42%, slightly more men than women. Divide into groups according to age:18-60y proportion 86.6 1%,<18y proportion 8.93%,>60y proportion 4.46%. The herb of which the frequen-cy is more than 50% is as follow:Liquorice(gancao)(98.44%), Poria(Fuling)(97.92%), Radix Rehmanniae Recens(Shengdihuang)(97.40%), the Root Bark of the Peony Tree(D-anpi)(94.27%), Bistortae(Quanshen)(91.67%), Rhizoma Smilacis Glabrae(Tufuling)(81.77 %), Herba Hedyotis(Baihuasheshecao)(67.71%), Rhizoma Atractylodis(Cangzhu)(60.94%), Radices Paeoniae Alba(Baishao)(59.90%), Radix Paeoniae Rubrathe(Chishao)(56.77%), Solanum lyratum(Baiying)(55.21%), the Root of Red-rooted Salvia(Danshen)(54.69%), Rhizoma Imperatae(Baimaogen)(50.52%). The frequency of use of heat-clearing herb up to the maximum(1622), followed by tonic drugs(557), third is to remove blo-od sta sis drugs(237). In the analysis of the syndrome, the core syndrome are blood h-eat, b1 ood stasis, wind dryness, phlegm dampness, blood deficiency, spleen deficiency, liver qi stagnation, qi deficiency, yin deficiency. The core herb of treating blood heat syndr ome are as follow:Radix Rehmanniae Recens(Shengdihuang), Poria(Fuling), Liquorice(g ancao), the Root Bark of the PeonyTree(Danpi), bistorta(Quanshen), Rhizoma Sm-ilacis Glabrae(Tufuling); blood heat withdampness syndrome:Rhizoma Smilacis Glabra-e(Tu fuling), bistorta(Quanshen), Radix Rehmanniae Recens(Shengdihuang), the Root B-ark o f the Peony Tree(Danpi), Poria(Fuling), Liquorice(Gancao), Rhizoma Imperatae(Ba-imao gen), cortex dictam(Baixianpi); blood stasis and wind dryness:Wine Zaocys dhu-mnad es(Wushe), Radix Paeoniae Rubrathe(Chishao), Radix Paeoniae Alba(Baishao), de-ndrob ium stem(Shihu), bran fried Rhizoma Atractylodis(Chaocangzhu), Poria(Fuling), Radix Glycyrrhizae(Gancao), radix curcumae(Yujin), Hedyotis diffusa Willd(Baihuashes-heca); blood stasis and blood deficiency syndrome:Radix Salviae Miltiorrhizae(Danshen), Ra dix Paeoniae Rubrathe(Chishao), R-hizoma Dioscoreae Hypoglaucae(Bixie), bistort rhizo me(Quanshen), Poria(Fuling), RadixGlycyrrhizae(Gancao), Radix Paeoniae Alba(B-aisha o), Rhizoma Smilacis Glabrae(Tufuling).Conclusion:Professor Xu Xian believes that psoriasis should be treated based on "blood". And the main pathogenesis of psoriasis is blood heat. Removing pathogenic heat from blood method is throughout treating time. The syndrome differentiationmain-ly includes blood heat, blood stasis, blood deficiency. Clinically, according to the ac-ute phase and chronic period, psoriasis is divided into four types to treat. The main t-ypes are blood heat, blood heat with dampness syndrome, blood stasis and wind dryn-ess, blood stasis and blood deficiency, respectively using Jiyin Prescription, Jiyin 2 Pr-escription, Danshejiedu Prescription, Danshejiedu 2 Prescription to treat. The core herb-s to treat psoriasis of blood heat are Rhizoma Smilacis Glabrae(Tufuling), bistorta(Qu-anshen), Radix Rehmanniae Recens(Shengdihuang), the Root Bark of the Peony Tree (Danpi). The core herbs to treat psoriasis of blood stasis are Radix Salviae Miltiorrhi-zae(Danshen), Wine Zaocys dhumnades(Wushe), Radix Paeoniae Rhizoma Dioscoreae Hypoglaucae(Bixie), Rubrathe(Chishao), Radix Paeoniae Alba(Baishao). Poria(Fuling) a-nd Radix Glycyrrhizae(Gancao) as one of the couplet medicines, is basically used in all the treatment of psoriasis prescription. External using Chinese medicine basic presc-ription are as follow:Artemisia argyi(Aiye), glabrous greenbrier rhizome(Tufuling), Ru-mex madaio(Tudahuang), cortex dictamni(Baixianpi), purslane(Machixian). A topical cr-eam named fufangwubeizigao can thin skin, shiduruangao can eliminating dampness a-nd relieve internal heat or fever, jiaweiwushigao can eliminating dampness and relieve itching, zhiyangrunfushuang can moisturizing dryness to relieve itching, silicone cream can play the role of skin care. And Professor Xu often treats psoriasis combining w-ith western medicine such as AVI A, vitamin B6, folic acid tablets, Cetirizine Hydroc hloride Tablets. And he often paids great attention to the education, monitoring and p-revention of patients.