Study On The Correlation Between PMS And Neurotransmitters Based On BDI, BAI And TCM Symptoms

In recent years, with the continuous development and progress of society, premenstrual syndrome (PMS) incidence rate has increased year by year, the group also by growth period gradually to a younger age trend. Because of the characteristics of this disease, it is often ignored by the patients themselves, therefore, although it has a high incidence rate, the treatment rate is low. And the anxiety disorder (PMDD) is a severe performance of PMS, in addition to the serious impact on women’s state of mind, quality of life, because it is likely to trigger violence and suicidality become one of the risk factors of social instability, the influence it brings has been paid more and more attention.Correlation of incidence angle of table and liver Tibet blood advocate sparse release function in the women’s menstrual cycle is an important regulatory role, including the early and the later relation closely. Therefore, this study selected premenstrual (corpus luteum period) and the late (late follicular phase) for specific research phase to self-made "traditional Chinese medicine symptom observation table ", Beck Depression Inventory (BDI), Beck Anxiety Scale (BAI) as the foundation, through the neurotransmitter detection, the proposed from etiology of PMS and brain neurotransmitter, and further explore the PMS with liver correlation, in order to explore the disease pathogenesis will provide theoretical and clinical basis.Materials and methods1 Subject object:Young female in the school of Beijing university of Chinese medicine.2 Preliminary screeningr:to fill in the "PMS status questionnaire", screening eligible subjects.3 Inclusion and grouping:according to PMS diagnostic criteria, inclusion criteria, exclusion criteria,divide the participants into PMS group (Nl) and healthy controls (N2).4 Research methods4.1 Scale4.4.1 All fill in the object into the PMS group and healthy controls.4.1.2 Fill in time phase into the group after the first menstrual cycle of follicle and corpus luteum middle-late late.4.1.3 Scale selection fill in the from of the "TCM symptom observation table"(the following abbreviation "symptom integral table"),BDI,BAI.4.2 Laboratory index determination4.2.1 Test object with scale.4.2.2 Testing phase in the group after the first menstrual cycle of follicle and corpus luteum middle-late late,have the blood test taken on an empty stomach at 8-9 a.m.4.2.3 The choice of test indicators:female sex hormone(estradiol (E2), progesterone (P),follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL),testosterone (T)), neurotransmitter(angiotensin-2 (AngⅡ),5-hydroxytryptamine (5-HT), acetylcholine(ACH), neuropeptide Y(NPY), corticotropin releasing hormone(CRH)).5 Statistical methods:with SPSS 22.0 sofrware,using the chi-square test,Single factor variance analysis,independent sample t test,paired T test,Pearson correlation analysis method for statistical analysis.Results1 PMS status questionnaireThere was no significant difference between the two groups. PMS group and healthy controls have significant difference in the scores of symptom, depression and anxiety scores.2 Score table of the TCM symptom observationPMS group scores were significantly higher than healthy controls,PMS group scores were significantly higher in corpus luteum middle-late late ovarian follicles(P<0.05), healthy controls during the two comparison there was no significant difference.3 Score of BDI and BAIPMS group of BDI in corpus luteum period is significantly higher than late ovarian follicles (P<0.05),PMS group is higher than the healthy subjects.scores of BAI,PMS group is higher than the healthy subjects, during the two periods there was no significant difference.4 Sex hormonesE2 and P in the late follicle were significantly lower than that in corpus luteum middle-late late,and the rate of E2/P in the corpus luteum middle-late late was significantly lower than that in corpus luteum middle-late late.FSH during the late follicle was significantly higher than that in corpus luteum middle-late late.PRL level in the late follicle was significantly lower than that of the corpus luteum middle-late late.LH and T in each group between each period has no significant difference.5 Correlation of "symptom integral table" and BDI,BAIThe "syndrome" score of two groups in the two phases were significantly associated with BAI,BDI score.6 Correlation of "symptom integral table" and neurotransmittersCertain symptom scores in each group between each period have significantly correlation with neurotransmitters.7 Correlation of BDI,BAI and neurotransmittersPMS group of BDI and BAI in corpus luteum middle-late late both have significantly correlation with CRH.Conclusion1 The onset of PMS and closely related to the main pathogenesis is liver storing blood.2 The female of higher degree of depression is more likely to have PMS.3 PMS has a degree of correlation with neurotransmitters, which has a certain degree of positive correlation with 5-HT, CRH and AngⅡ, and a certain degree of negative correlation with NPY.