Meta - Analysis Of The Therapeutic Effect Of Traditional Chinese Medicine Combined With Chemotherapy On Colon Cancer

Purpose:to analyse the scientific nature of the Chinese traditional medicine combination chemotherapy for colon cancer, effectiveness, an objective evaluation, for application of Chinese medicine in the treatment of colon cancer to provide evidence-based medical evidence, to guide the clinical medication.Methods:evaluation by the two system independently to retrieve the China Biology Medicine disc(CBMdisc), China National Knowledge Infrastructure(CNKI), China Science and Technology Journal Database(VIP),Pub Med and other electronic databases. Retrieval scope includes prior to March 2016 in accordance with randomized controlled trial(RCTs) of all research literature, eliminate duplicate documents and non clinical literature related literature, the qualified documents. In case of differences, the two sides discussed or by third evaluation personnel to help decide whether included. According to the row standard into 16 articles. Using the new Jadad scale to evaluate into 16 articles, excluding score 2 points or less, use Review Manager5.3 statistical software for Meta analysis study.Results:1. The participants included with 16 references, a total of 1286 cases. Which the number of cases for treatment group 540 examples, the control group cases to 746 cases; Treatment group adopt traditional Chinese medicine compound combination chemotherapy, the control group were pure chemotherapy.2. The efficient outcome indicators in five references adopted as the evaluation index,x2=3.28,P=0.51>0.1,I2=0%<50%, the combined effect of the amount(OR) = 2.55, 95%CI= [1.27, 5.14], the overall effect, Z = 2.63, P < 0.001.3. Three of the article referred to the transfer of recurrence, x2=0.32,P=0.85>0.1,I2=0%<50%,the combined effect of the amount(OR) = 0.36, 95% CI = [0.21, 0.62], the overall effect,Z = 3.72, P < 0.01.4. Six of them adopted the KPS score, x2=1.40,P=0.92>0.1,I2=0%<50%,the combined effect of the amount(OR) = 3.46, 95% CI= [1.93, 6.22], the overall effect, Z = 4.16, P <0.0001.5. 11 article mentioned the leucocyte â…¡ degrees above, reduce the x2=15.91,P=0.04<0.1,I2=50%,merge effect size(OR) = 0.57, 95% CI = [0.39, 0.83], the overall effect, Z = 2.89, P< 0.01.6. 9 to observe the incidence of nausea and vomiting, x2=18.78,P=0.02<0.1,I2=57%>50%,merge effect size(OR) = 0.30, 95% CI = [0.20, 0.44], the overall effect, Z = 6.21, P <0.00001.7. Three of the article records the syndromes curative effect, x2=0.54,P=0.76>0.1,I2=0%<50%,the combined effect of the amount(OR) = 4.70, 95% CI = [2.24, 9.88], the overall effect,Z = 4.08, P < 0.0001.8. 2 article adopted European determination of quality of life scale(EORTC QLQ C30)measurement function latitude and the total evaluation points to improve the quality of life,x2=0.14,P=0.70>0.1,I2=0%<50%,standardized mean differences(MD) = 7.65, 95% CI =[4.16, 11.13], the overall effect, Z = 4.30, P < 0.0001.Conclusion:The traditional Chinese medicine with western medicine chemotherapy therapy in improving efficiency and quality of life, prevention of recurrence of colon cancer metastasis, resist leukopenia, prevention and treatment of nausea and vomiting than simple chemotherapy has significant advantages in aspects.