Finite Element Analysis Of Solute Transport In Loaded Bone Based On Fluid - Solid Coupling

Bone is a vital organ of the human body which has the important physiological function. The same as the other organizations, bone tissue in a dynamic three-dimension environment, its internal flow and solute transport play an important role in maintain tissue function and activity of ontology. Fluorescence recovery after photobleaching (FRAP) is a major method of fluid flow and solute transport’s research now, but due to the limitations of optical imaging technology, FRAP is just for observation and analysis of 50 microns area below the periosteum. This article embarks from the theory of mixture and finite element method, study on the finite element simulation of adult rat tibia, and combine FRAP experiments to validate the finite element method applied to the research of bone fluid flow and solute transport. This article’s main studies and content including:(1) Used two-dimensional tomography of CT images and Mimics software platform to achieve three-dimension reconstruction of adult rat tibia. Hypermesh was used to mesh tibia model, The grid model three-dimension reconstruction after has a very high similarity with tibial material.(2) Established a model of two phase-solute,obtained the related parameters of adult rat tibia mode including elastic modulus, porosity, permeability. Used FEBio biological finite element simulation software, Obtained solute transport properties of lacuna-canaliculi system of different solute difffusivity and load strength. Discussed the concept of transport enhancement degrees, discussed the influence of diffusivity and load strength for transport enhancement degree.(3) Aimed at region under the periosteum area of adult tibia(50μm), Combined the data of finite element method and fluorescence recovery after photobleaching experiment. Controlled solute transport enhancement degree of the lacuna-canaliculi system in same load condition. Discussed the effects of the solute transport phenomena in the LCS system of different load strength, Verified the feasibility of Bone fluid flow and solute transport research by using Biological finite element method.(4) By using the finite element method, further study on flow field distribution information in deep area of the bone. Gained bone-inner distribution of fluid pressure, fluid flow, solute flow under different load condition. Making further discussion about effect of LCS system’s luquidity for the increase of porosity.