Preoperative NLR And PLR Predictive Value Of 1 Year Survival Rate In Patients With Pancreatic Cancer

ObjectiveTo evaluate whether neutrophil-lymphocyte ratio(NLR)、 platelet-lymphocyte ratio(PLR) can be the independent predictor on one year survival rate after operation in patients with pancreatic cancer.MethodsA retrospective study was performed to analyz the clinical data of 113 cases with pancreatic cancer who accepted surgery treatment firstly in Peking Union Medical College Hospital from Aug.2011 to Dec.2014. Patients were divided into different groups according to the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte (PLR) calculated from the peripheral venous blood, NLR≤3 and NLR>3 were classified as low and high NLR group, PLR≤177 and PLR>177 were calssified as low and high PLR group, then comper their one year survival rate. Adopting the Cox model to analyze the data and evaluate where PLR or NLR can be the independent predictor on one year survival rate after operation in patients with pancreatic cancer.Results1. The one year survival rate of pantients with low preoperative NLR (n=67) was significantly better than that of those with high preoperative NLR (89.55% VS 56.52%). The difference of one year survival rate between low preoperative NLR group and high preoperative NLR group was statistically significant (P<0.001).2. The one year survival rate of pantients with low preoperative PLR (n=69) was significantly better than that of those with high preoperative PLR (88.41% VS 56.82%). The difference of one year survival rate between low preoperative PLR group and high preoperative PLR group was statistically significant (P<0.001)3.Choose the significant variables from the univariate analysis and then import them to Cox model to analyze again. Cox model showed the preoperative NLR and PLR are independent predictor of prognosis.Conclusions1. The higher preoperative NLR and (or) PLR in patients with pancreatic cancer can predict the lower one year survival rate after operation.2. Preoperative NLR=3 as the prognosis of patients with pancreatic cancer to determine the cutoff value, preoperative NLR>3 prognosis than NLR≤3 in patients with poor prognosis.3. Preoperative PLR=177 as the prognosis of patients with pancreatic cancer to determine the cutoff value, preoperative PLR>177 prognosis than PLR≤177 in patients with poor prognosis.4. Preoperative NLR and PLR can be used as prognosis patients with pancreatic cancer.