Research On The Application Of Portable Electro - Spinning Device As Wound Nursing Equipment

The electrospun nanofibrous matrix has several particular intrinsic properties such as its nanometer diameter, high porosity, structure and functional biology similar to the ECM, which makes it particularly interesting for wound healing applications. In order to accelerate the transformation of electrospinning theoretical study to application and production, we put forward three portable electrospinning apparatus including battery-operated, airflow-assisted and hand-operated devices and make a research on their application feasibility, which proceeds from the following situation: portable electrospinning apparatus as mobile care medical equipment, in situ electrospinning on wound and succinct application process of electrospun dressing.First of all, a battery-operated electrospinning apparatus is presented and its working performance, design principle and electrospun materials are introduced in detail. With high encapsulation, the apparatus has the around size of a palm and can realize the “customized dressing” by in-situ electrospinning of polymer materials on wound, which conduces to a timely and effective wound care. Due to its independence and portability, this apparatus can be used as a medical device for wilderness and remote travel, accident scene, home nursing and battlefield rescue, potentially accelerating the practical process of electrospun dressing.Secondly, we use in situ airflow-assisted electrospinning technique to fabricate cyanoacrylate hemostatic dressing on liver wound and test its biosecurity. Additional airflow can precisely control the deposition range of electrospun fibers, improve the operation safety and effectively avoid abdominal adhesion. In addition, this novel technique can reduce the dosage of cyanoacrylate by almost 80%. It proves the feasibility, practicability and superiority of using novel electrospinning technique to directly fabricate internal hemostatic dressing of medical operation, which provides a good potential application direction to electrospinning technique.Finally, we design a melt electrospinning setup based on a hand-operated Wimshurst generator, introduce its working principle and operation in detail and successfully fabricate PCL、PLA biological microfibers. The contact temperature and adhesion force between melt-electrospun fibers and biological tissue are tested and the result proves the feasibility of direct in-situ melt electrospinning on wound surface. The apparatus can effectively avoid the solvent toxicity of solution electrospinning and make the operation safer. This technique facilitates the application of melt-electrospun fibers in wound dressing to some degree.