The Synthesis, Structure And Properties Of Ether Amine Schiff Base And Its Transition Metal Complexes

Schiff base complexes, which contains imine group, are obtained by the condensationreaction of various formyl-or keto-and primary amine-precursors. Schiff bases can befunctionalized by inserting appropriate groups in the precursors and they generally cancontain additional donor group which makes them good candidates for metal ioncomplexation. A wide variety of different schiff base compounds have been designed toascertain correctly the role of the different donor atoms, their relative position, the numberand size of the chelating rings formed, the flexibility and the shape of the coordinatingmoiety on the selective binding of metal ions. Schiff base metal complexes not onlypossess unique molecular structures, but also display many novel properties in catalysis,medicine, analysis, photochromism, corrosion, agriculture, ocean, material andbiochemistry etc. Special care is devoted to their potential applications in these fields. It’sgreat importance to synthesis and characterization of schiff base complexes. Schiff baseswith2-(2-Aminoethoxy)ethanol,2-amino-2-ethyl-1,3-propanediol and4-Phenoxy-phenylamine,3-Amino-4-hydroxy-benzoic acid were designed and synthetizedin this paper and16crystal structures of these schiff base ligands or it’s complexes havebeen determined. The vitro cytotoxic and the interaction between these complexes withDNA and BSA were investigated.main work:1. Aliphatic ether amine Schiff base ligands including: HL1(2-{[2-(2-Hydroxy-ethoxy)-ethylimino]-methyl}-phenol), HL2(3-{[2-(2-Hydroxy-ethoxy)-ethylimino]-methyl}-naphthalen-2-ol), HL3(4-Chloro-2-{[2-(2-hydroxy-ethoxy)-ethylimino]-methyl}-phenol), H2L4(2-ethyl-2-(2-hydroxybenzylideneamino)propane-1,3-diol) and eight complexes with Schiff baseligands were synthesised and characterized.2. Aromatic ether amine Schiff base ligands including: HL5(2-[(4-Phenoxy-phenylimino)-methyl]-phenol), HL6(3-[(4-Phenoxy-phenylimino)-methyl]-naphthalen-2-ol), HL7 (4-Hydroxy-3-[(2-hydroxy-benzylidene)-amino]-benzoic acid) and eight complexes withSchiff base ligands were synthesised and characterized.3. The properties test(1) Interaction between these complexes with CT-DNA has been studied byabsorption, emission titration methods and CD spectra.(2) Interaction of these complexes with BSA was also investigated using fluorescence,UV-visible and synchronous fluorescence spectroscopic methods.(3) The magnetic properties of complexes A1and A13were researched, the resultsshow that complexes of A1and A13present the antiferromagnetic interaction.(4). Cytotoxicities of free ligands: L6and complexes A9-A13against cancer cell linesare determined by MTT method.