Preparation Of Non-spherical Mesoporous Silica Nanoparticles And Their Applications In The Biomedicine And Catalysis

In recent years, serious problems such as environment, resources, disease, set aserious threat to human survival. Environmental pollutions occurring in the process ofindustrial have become one of the most important problems in the sustainabledevelopment of human society, waste water, waste gas and so on have caused greatdamage to the environment. Harmful substances including PM2.5resulted in a greatincreasing in cancer and other disease, such hazard human disease has gained greatattention of the scientific community, the medical profession and government. Theemergence of nanotechnology has brought new hope to solve this problem. In virtueof its unique physical and chemical properties, nanomaterials shows great advantagesin the field such as industry, environment, energy and biomedical. Consequently, todevelop a highly efficient, cheap and stable multifunctional nanocomposite used tosolve many problems is of great significance. In view of this, the low cost, excellentbiocompatibility hollow mesoporous silica was chose as the research object. From theperspective of size and morphology of the material the hard template technology wereemployed with ferric oxide as the template, by controlling the size and morphology ofthe template, the study successfully controlled the size and morphology of thetemplate. Except for hard template method, amination modification, goldnanoparticles loading, sol-gel method and effective organic functionalization werealso used. Through A series of chemical cutting, a highly efficient, stable andbiological compatibility of controlled drug delivery and catalysis system was build.Such a multi-functional nanocomposite displayed practical potential in the field ofcatalysis and biological targeting performance. Such an all in one system wasestablished to give an access to the solution of the problem involved biologicalcompatibility, relatively low drug load rate, high drug pre-release and singularfunction. The synthesis, modification mechanism of nanomaterials was effectivelyrevealed by many kinds of scientific apparatus such as TEM, SEM, XRD, BET, VSMand so on. A549cells and Hela cells were utilized to access the anti-cancer activity. What’ more, the same catalysts assessment system using Nitrophenol as templatemolecules was used to estimate the catalytic performance.The main structure is asfollows:The first part: with a purpose to synthesis shape controllable iron oxidenanoparticles, the temperature time, material ratio, iron sources and reaction processand other factors during the preparation of the template were systematically studied.The main principle used here is some kinds of inorganic ions could have a greatinfluence on the growth of ferric oxide crystal. The growth mechanism of the multipletemplate was studied by means of XRD, TEM, SEM, VSM, Raman and so forth. Then,a kind of core-shell nanocatalyst with controllable morphology include capsule-like,rice-like, cube sugar like and diamond-like that can be abbreviated toFe2O3@SiO2-Au@mSiO2were prepared via hard template method and sol-gel method.It has been confirmed that such a multishape nanocomposite have a good performancein catalytic reduction of4-nitrophenol.In the second part we studied the shape controllable hollow mesoporous silica inthe biomedical field. The same synthetic strategy was developed for the preparation ofshape controlled hollow mesoporous silica nanoparticles (HMSNs) typicallydisposing the loading process of Au nanoparticles (AuNPs). In order to improve thespecific uptake of cells, HMSNs were further functionalized with folic acid (FA) andpolyethylene glycol (PEG). Such a shape controlled HMSNs were used as a drugdelivery system to study the effect of shape on the properties on drug loading andrelease in vitro environment. Hela cells and A549cells were chose as model cell, tostudy the biotargeting, biocompatibility of the materials. The result shows that ricelike HMSNs have a great ability to kill cancer cells.In the third part we studied the soft template method to prepare amulti-morphology mesoporous silica. Preparation experiments investigated the effectsof different types of silicon source, surfactant type, reaction temperature on themorphology of the ultimate silica nanoparticles. And rod like and tubular likemesoporous silica nanoparticles were successfully prepared, its formation mechanismwas also explored. On the base of this work, we studied the influence factors of preparing iron oxidetemplate under hydrothermal conditions by controlling concentration of sulfate ion.Technology to prepare versatile α-Fe2O3template and shape controllablenano-catalysts was obtained. We also exploreed the preparation and biologicalproperties of the shaped hollow mesoporous silica. Double surfactant and doubleSi-sourceby double tubular SiO2synthesized nanomaterials have a betterunderstanding and knowledge, and clearly the future research directions.