Study On The Synthesis Of Esters From Aldehydes Or Carboxylic Acids With Dichloroalkane Under Mild Conditions

Ester is an important type of compounds, widely exits in natural products, pharmaceuticals,functional advanced materials, pesticides and commodities. Sulfuric acids, various transitionalmetals and long reaction time were required in the traditional procedures. Therefore, a rapid,efficient, practical and green access to ester is highly desired in terms of low carbon economyand green chemistry.Novel methodologies to synthesize methylene diesters,2-chloroethyl esters,3-chloropropylesters and their derivatives from the reaction of carboxylic acids or aldehydes withdichloroalkylanes were mainly explored in this thesis. These transformations involved anuleophilic substitution reaction of alkyl halides with the carboxylates, which derived fromcarboxylic acids and potassium hydroxide. Various parameters were screened to optimize thereaction condition, such as bases, solvents and reaction temperature. Under the optimal reactionconditions, the scopes of substrates, various carboxylic acids or aldehydes, were explored. Twoseries of esters were provided in good to excellent yields.The methodologies to build ester in this thesis feature with high efficiency, wide functionalgroups tolerance, commercially available starting materials and environmentally friendliness.