Study On The Synthesis And Properties Of Cucurbit[6]uril Derivatives

Cucurbituril is a kind of new supramolecular macro ring compound, because ofthe special structure of cucurbituril，researchers pay amount attention on it. Today，theresearches of cucurbituril derivatives become hot due to the poor solubleness ofcommon cucurbituril. In this article, the properties of metal coordination andhosts-guests chemistry were researched on two kinds of cucurbituril derivativesrespectively.The first chapter of this thesis described the origin and structure character ofcucurbituril in detail, and the synthetic methods of cucurbituril derivatives weredescribed at the same time. Cucurbituril has some potential application value due to it’sspecial structure, and the research situation and prospect of it was introduced as well.In the second chapter of this thesis, two kinds of cucurbituril derivatives weresynthesized, that was perhydroxycucurbit[6]uril, which was obtained by oxidate thecommon cucurbit[6]uril directly, and when synthesized cyclohexyl-substitutedcucurbit[6]uril, cyclohexyl glycoluril was obtained first, then polymerized it to gotcyclohexyl-substituted cucurbit[6]uril. At the same time, four N-N’-dialkyl-4,4’-bipyridyl homologues were synthesized and charactered by H1NMR.The coordinations between perhydroxycucurbit[6]uril and alkali metal ions werestudied in the third chapter of this thesis, and three different crystals were obtained andcharactered by X-Ray single-crystal diffractometer. After compared these three crystals,it was found that the coordinations between perhydroxycucurbit[6]uril and alkali metalions were different due to the diverse radius of the metal ions.In the fourth chapter of the this thesis, the hosts-guests chemistry ofcyclohexyl-substituted cucurbit[6]uril was studied, after compared the H1NMR of pureguests moleculars and the mixture of guests moleculars and cyclohexyl-substitutedcucurbit[6]uril, the probable interactions between them were predicted. It is found that,the alkyl chains of the guests molecular were much easer to enter into the cavity ofcyclohexyl-substituted cucurbit[6]uril than the pyridine parts of the organic molecular.